氯沙坦和依那普利联合用药对肾性高血压的影响(1)
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[摘要] 目的:观察氯沙坦和依那普利联合用药对肾性高血压和肾功能的影响。方法:将150例肾性高血压患者随机分成三组,每组50例,对照组分别服用氯沙坦(50 mg/d)、依那普利(20 mg/d),实验组服用氯沙坦(25 mg/d)和依那普利(10 mg/d),然后比较不同分组用药对肾性高血压及肾功能的影响。结果:联合用药组的降压效果较对照组更明显(t=15.53、14.54,P<0.05);联合用药组的肾功能较对照组改善明显(t=12.14、12.78,P<0.05)。结论:氯沙坦和依那普利联合用药能有效控制患者肾性高血压,并能明显改善肾功能。
[关键词] 肾性高血压;肾功能;氯沙坦;依那普利
[中图分类号] R544.1+4[文献标识码]B [文章编号]1673-7210(2010)06(b)-051-03
Effect of Losartan and Enalapril coalescent action on renal hypertension
WAN Rongwen1, TANG Jianjun2, JIANG Delin3, GUAN Yan1, DENG Yangchun3
(1.Department of ICU, Hu'nan Province Changsha City Central Hospital, Changsha 410004, China; 2.Department of ICU,Xiangya Second Hospital, Central South University, Changsha410004, China; 3.Department of Cardiovascular Medicine, Hu'nan Province Yongzhou City People's Hospital, Yongzhou 425006, China)
[Abstract] Objective: To observe the effect of Losartan and Enalapril coalescent action on renal hypertension. Methods: 150 cases of renal hypertension were randomly divided into three groups that each group had 50 examples, which respectively took Losartan (50 mg/d), Enalapril (20 mg/d), Losartan (25 mg/d) and Enalapril (10 mg/d). Then three groups' changes of renal hypertension and function were compared. Results: Compared with pretherapy, hypertension of took Losartan and Enalapril groups was obviously changed (t=15.53,14.54, P<0.05); compared with pretherapy, renal function of took Losartan and Enalapril groups was more available change (t=12.14, 12.78, P<0.05). Conclusion: Losartan and Enalapril coalescent action can effectively control renal hypertension of patient and improve renal function.
[Key words] Renal hypertension; Renal function; Losartan; Enalapril
慢性肾功能不全患者常有不同程度的血压增高,少数可发生恶性高血压,出现高血压后又可使肾功能进一步减退,促使血压继续升高,造成恶性循环。肾性高血压患者控制血压是防止肾脏病变持续发展的关键,但需大剂量用药才能奏效,临床常产生一系列副作用如颜面潮红、头昏、头痛、下肢水肿等[1]。临床治疗时常分别选用氯沙坦或依那普利,两者均有降压、降低蛋白尿、保护肾脏和延缓肾脏病进展的作用,而两药联合应用治疗肾性高血压的作用报道较少。本研究观察氯沙坦和依那普利联合用药对肾性高血压的控制效果和对肾功能的影响。
1 资料与方法
1.1 一般资料
选取2004年1月～2009年12月在长沙市中心医院慢性肾小球肾炎合并高血压患者150例,其中男84例、女66例,年龄20～50岁,平均37 ......
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