乙型肝炎疫苗免疫效果回顾性评价(1)
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[摘要] 目的:对从化市学龄前儿童乙型肝炎疫苗免疫效果进行回顾性分析,为我市制订乙型肝炎免疫策略提供参考数据。方法:通过对从化市1995～2005年学龄前儿童进行乙型肝炎感染的血清学检测,分析从化市学龄前儿童乙型肝炎病毒表面抗原(HBsAg)携带率,结合对从化市学龄前儿童乙型肝炎疫苗接种率等资料进行对比分析,并将当年该市农村学龄前幼儿HBsAg 携带率进行比较,用以对从化市学龄前儿童乙型肝炎疫苗免疫效果进行回顾性评价。结果:随着乙型肝炎疫苗免疫接种率的逐年上升,从化市学龄前儿童乙型肝炎病毒表面抗原携带率则逐年下降,学龄前儿童HBsAg携带率由1995年的15.8%下降到2005年的4.5%(P<0.05)。乙型肝炎保护性抗体(抗-HBs)则逐年上升,由1995年的39.9%升高到2005年的71.3%(P<0.05)。同一时期内,城区学龄前儿童HBsAg携带率较农村儿童HBsAg携带率明显降低(P<0.05)。结论:对学龄前儿童进行有组织有计划的乙型肝炎疫苗免疫接种,能够有效地降低学龄前儿童乙型肝炎病毒表面抗原(HBsAg)携带率;城区儿童乙型肝炎疫苗免疫接种率及接种效果均高于农村儿童。加强对乙肝易感人群的有计划的免疫,是降低乙肝感染的有效途径。
[关键词] 乙肝疫苗;被动免疫;乙型肝炎
[中图分类号] R516.2[文献标识码] A [文章编号] 1673-7210(2010)06(c)-128-02
Retrospective evaluation about immune effective of hepatitis B vaccine
ZHANG Dongwu
(Out-Patient Department of the Center Hospital of Conghua City, Conghua 510900, China)
[Abstract] Objective: To analyse hepatitis B vaccine of preschool children in Conghua city retrospectivly, and provide reference data to the city developed for hepatitis B immunization strategy. Method: Of Conghua city in 1995-2005 for preschool children infected with the hepatitis B serological detection, the data of preschool children hepatitis B virus surface antigen (HBsAg) carriers, combination of Conghua city preschool children hepatitis B vaccination rate data were analyzed, and retrospective evaluation was carried out. Results: With the hepatitis B vaccination rate has increased, Conghua City preschool children HBsAg carried rate has declined each year, HBsAg preschool children from the rate 15.8% in 1995 fell to 4.5% in 2005 (P<0.05). Protective hepatitis B antibody (anti-HBs) was on the rise every year,39.9% in 1995 increased to 71.3% in 2005(P<0.05). The same period, city preschool children HBsAg rate comparing with rural children of HBsAg was significantly lower (P<0.05). Conclusion: For pre-school children in an organized and planned for the hepatitis B vaccination, to be effective in lowering preschool children HBsAg carrier rate; city children hepatitis B vaccination and immunization rates are higher than that of rural children ......
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