胎儿生长受限与抗心磷脂抗体的相关性(1)
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[摘要] 目的：探讨抗心磷脂抗体与胎儿生长受限发生的关系，为胎儿生长受限的早期诊断和预防提供新的思路。方法：记录我院正常妊娠产妇及抗心磷脂抗体阳性产妇的妊娠结局、分娩方式、新生儿出生体重和Apgar′s评分，并进行回顾性分析。结果：胎儿生长受限组抗心磷脂抗体阳性者胎儿生长受限发生率为15.63%，对照组抗心磷脂抗体阴性者胎儿生长受限发生率为1.67%，两组比较，有显著性差异(P<0.05)；胎儿生长受限组抗心磷脂抗体阳性比率为18.60%，对照组为3.36%，两组比较，有显著性差异(P<0.05)。结论：胎儿生长受限孕妇血清抗心磷脂抗体阳性在我院行产前检查的孕妇中明显升高，提示胎儿生长受限的发生与抗心磷脂抗体阳性有关。抗心磷脂抗体阳性是胎儿生长受限发生的病因之一。
[关键词] 胎儿生长受限；抗心磷脂抗体；产前检查
[中图分类号] R714.43[文献标识码]A [文章编号]1673-7210(2010)10(b)-036-02
Study on the correlation between anticardiolipin antibody and fetal growth restriction
YE Yanzhen, CHEN Jianyu, LIU Jianling, LI Wenhua
(The People's Hospital of Nanhai District in Foshan City, Guangdong Province, Foshan 528200, China)
[Abstract] Objective: To investigate the relationship of anticardiolipin antibody (ACA) and fetal growth restriction (FGR), and to provide new methods for the early diagnosis and prevention of FGR. Methods: In our hospital, pregnancy outcome, pregnancy methods, birth weight and Apgar's score of normal pregnant women and pregnant women with ACA-positive were recorded, and retrospectively analyzed. Results: AcA-positive probability of occurrence of FGR in FGR group was 15.63%, compared with ACA-negative 1.67% of control group was significantly higher, there was a significant difference (P<0.05). FGR group of ACA-positive rate of 18.60% was significantly higher than 3.36% of the control group, there was a significant difference (P<0.05). Conclusion: FGR maternal serum ACA levels are significantly increased, indicating that there is a relationship of the occurrence of FGR and the ACA-positive. ACA-positive is one of the causes of FGR occurred.
[Key words] Fetal growth restriction; Anticardiolipin antibodiy; Pregnacy check-up
胎儿生长受限(fetal growth restriction，FGR)是指孕37周后，胎儿的出生体重小于2 500 g，或低于同孕龄平均体重的2个标准差；或低于同孕龄正常体重的第10百分位数，是围生期的重要并发症。目前子宫胎盘血流障碍与不良妊娠结局的研究得到广泛关注。抗心磷脂抗体(anticardiolipin antibody，ACA)是结合在细胞膜上磷脂抗原中的一种新型的自身免疫性抗体，可以累及多系统、多脏器，影响胎盘结构及破坏其功能时，导致母胎物质交换障碍和胎儿的慢性缺氧，造成FGR等不良妊娠的发生，本研究主要探讨ACA与FGR发生的相关性，现报道如下：
1 资料与方法
1.1 一般资料
我院2008年11月～2009年11月进行围产保健检查孕妇，年龄20～34岁，选取孕前月经周期正常，末次月经记忆准确，结合早孕诊断，临床检查核对孕龄无误，单胎妊娠，共2 168例，于孕20～25周全部进行血清ACA测定 ......
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