培哚普利联合吲达帕胺对原发性高血压的疗效分析(1)
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[摘要] 目的：探讨培哚普利联合吲达帕胺对原发性高血压治疗的降压作用与不良反应。方法：选择我科2009年7～12月确诊为原发性高血压的患者90例，随机分为治疗组46例和对照组44例，排除继发性高血压患者，停服原用降压药物5 d以上，治疗前后查血、尿常规，心电图和血脂、血糖、肝肾功能，并记录。对照组采用吲达帕胺2.5 mg/d或5 mg/d降压；治疗组采用吲达帕胺2.5 mg/d和培哚普利4 mg/d治疗；8周后疗效评定。结果：治疗组总有效率为87.0%，而对照组总有效率为59.1%，组间差异有统计学意义(P<0.05)，且治疗组不良反应少。结论：培哚普利联合吲达帕胺治疗原发性高血压效果好，且不良反应少，值得临床推广应用。
[关键词] 原发性高血压；吲达帕胺；培哚普利
[中图分类号] R544.1[文献标识码]B [文章编号]1673-7210(2010)10(c)-064-03
Efficacy analysis of Perindopril combined with Indapamide in primary hypertension
TIAN Ming
(The Second Department of Cardiology, the First People's Hospital of Pingdingshan City, He'nan Province, Pingdingshan 467000, China)
[Abstract] Objective: To investigate the hypotensive effect and adverse reactions of Perindopril combined with Indapamide in primary hypertension. Methods: From July 2009 to December 2009 in our department, 90 patients diagnosed with essential hypertension were randomized groups, 46 cases of treatment group and 44 cases of control group, they were excluded secondary hypertension. These patients stopped taking antihypertensive drugs more than 5 days. Before and after treatment, the blood and urine routine, ECG and blood lipids, blood glucose, liver and kidney function were recorded. The control group treated with Indapamide 2.5 mg/d or 5 mg/d; the treatment group treated with Indapamide 2.5 mg/d and Perindopril 4 mg/d; the curative effect were assessed after 8 weeks. Results: The total effective rate of treatment group was 87.0%,and the control group was 59.1%, the difference was statistically significant(P<0.05), and the treatment group had less adverse reactions. Conclusion: Perindopril combined with Indapamide in the treatment of primary hypertension has good effect and less adverse reactions, it is worth popularizing.
[Key words] Primary hypertension; Perindopril; Indapamide
随着人口老龄化趋势的加快，心血管疾病已经成为威胁居民身体健康的主要疾病，培哚普利是一种血管紧张素转换酶抑制剂，是治疗高血压病的一线用药，吲达帕胺能对高血压病的治疗起很好的降压作用，联合用药可以提高疗效，最大限度地降低心血管发病率和死亡率。中国高血压防治指南提倡降压药物联合治疗，有利于提高患者的依从性，减轻不良反应，提高控制率[1]。我科选择培哚普利、吲达帕胺联合治疗高血压，取得很好的疗效，报道如下：
1 资料与方法
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