降钙素受体在骨转移瘤中的表达水平及意义(1)
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[摘要] 目的：通过检测CTR在18例骨转移瘤中的表达情况，初步探讨CTR与骨转移瘤之间的关系。方法：选取骨转移瘤患者18例，根据X线表现成骨表现组4例与溶骨表现组14例。应用免疫组织化学染色法检测CTR表达，并作出统计学分析。结果：18例骨转移瘤患者中，CTR阳性表达15例，阳性率为83.0%；10例正常骨组织中，CTR阳性表达3例，阳性率为30.0%，二者之间有非常显著性差异(P<0.01)。成骨表现组6例，CTR阳性表达3例，阳性率为50.0%；溶骨表现组19例，CTR阳性表达18例，阳性率为92.8%，二者之间有显著性差异(P<0.05)。结论：CTR在骨转移瘤中的表达水平高于正常骨组织，而且在溶骨型骨转移瘤中的表达水平高于成骨型骨转移瘤。
[关键词] 骨转移瘤；降钙素；降钙素受体；免疫组织化学染色
[中图分类号] R738.1[文献标识码]A [文章编号]1673-7210(2010)11(a)-015-03
The expression of calcitonin receptor in bone metastases and its significance
HAN Feng
(Department of Orthopedics, the First People′s Hospital of Shangqiu City, He′nan Province, Shangqiu 476100, China)
[Abstract] Objective: To discuss the relationship of calcitonin receptor (CTR) with bone metastasis through testing CTR in 18 cases of bone metastases. Methods: 18 patients with bone metastasis were selected, according to the X-ray showing osteogenesis performance group with 4 cases and osteolsis bone group with 14 cases. The expression of CTR is detected by immunohistochemical staining method and statistically analyzed. Results: Among 18 cases of patients with bone metastases, the expression CTR of 15 cases was positive with positive rate 83.0%, while normal tissue of 10 cases, CTR positive expression of 3 cases, positive rate 30.0%, there was a significant difference between them (P<0.01). Six cases of osteoblast performance group, 3 cases were positive CTR expression, dissolution rate 50.0%; 18 cases among 19 cases osteolsis performance group were positive CTR expression, dissolution rate 92.8% and significant difference between them (P<0.05). Conclusion: In the bone metastases expression level of CTR is higher than normal tissue and expression of in osteolytic bone metastases higher than level of osteoplastic bone metastases.
[Key words] Bone metastases； Calcitonin； Calcitonin receptor； Immunohistochemistry
骨转移瘤已经成为成年人中发病率最高的骨恶性肿瘤[1]，骨转移瘤原发疾病多为乳腺癌、前列腺癌及肺癌等，随病情进展常会引起病理性骨折、顽固性疼痛、高钙血症及神经压迫等并发症，严重降低了患者的生活质量。本文探讨降钙素受体(calcitonin receptor，CTR)在骨转移瘤中的表达情况，并探讨其相关性及表达意义，期望能为临床应用降钙素(calcitonin，CT)治疗骨转移瘤提供理论基础和依据，现报道如下：
1 资料与方法 ......
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