谷维素辅助治疗原发性高血压临床研究(1)
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[摘要] 目的：观察谷维素辅助治疗原发性轻、中度高血压的疗效。方法：将82例原发性轻、中度高血压患者随机分为两组，治疗组42例，给予谷维素片加硝苯地平缓释片；对照组40例，只给予硝苯地平缓释片；两组均治疗2个月，对收缩压、舒张压的最终下降幅度进行评定。结果：治疗组收缩压、舒张压的下降幅度更明显，与对照组比较，有显著性差异(P<0.05)，两组不良反应均较轻。结论：谷维素片加硝苯地平缓释片治疗原发性轻、中度高血压比单用硝苯地平缓释片疗效更好，谷维素片可增强高血压患者降压药的效果。
[关键词] 谷维素片；硝苯地平缓释片；原发性高血压
[中图分类号] R544.1[文献标识码]B [文章编号]1673-7210(2010)11(a)-063-02
The clinical research of Oryzanol in the assist treatment of primary hypertension
SHEN Yadong
(Department of Nephrology, Bo′ai Hospital of Rugao City, Jiangsu Province, Rugao 226500, China)
[Abstract] Objective: To observe the effectiveness of Oryzanol in the assist treatment of mild and moderate primary hypertension. Methods: 82 cases of mild and moderate primary hypertension were randomly divided into treatment group and control group, the treatment group were treated by Oryzanol and Nifedipine Sustained Release Tablets while the control group were treated by Nifedipine Sustained Release Tablets only, general treated for 2 months, the decrease amplitude of SBP and DBP were evaluated. Results: The decrease amplitude of SBP and DBP in treatment group were more obvious, compared with the control group, there was significant difference (P<0.05), the adverse reactions were mild in two groups. Conclusion: Oryzanol combined with Nifedipine Sustained Release Tablets in the assist treatment of primary hypertension has better effectiveness than used Nifedipine Sustained Release Tablets only, Oryzanol can enhance the effect of other antihypertensive drug.
[Key words] Oryzanol; Nifedipine Sustained Release Tablets; Primary hypertension
原发性高血压是最常见的心血管疾病且发病率呈逐年增高的趋势，可引起严重的心、脑、肾并发症，是脑血管意外、冠心病的主要危险因素，已成为中国人首位死因[1-2]。由于高血压用药时间长、患者依从性差、经济负担重等因素导致目前高血压的控制率仅从1991年的2.8%上升至2002年的6.16%，临床疗效不容乐观。2007年8月～2009年12月笔者用谷维素片加硝苯地平缓释片治疗高血压82例，旨在与单用硝苯地平缓释片时的降压效果和不良反应进行比较，以探讨谷维素对硝苯地平缓释片降压的影响，取得一定的疗效，现将结果报道如下：
1 资料与方法
1.1 一般资料
选择2007年8月～2009年12月我科门诊就诊的原发性高血压轻、中度患者共计82例，随机分成两组，均符合中国高血压防治指南修订委会制定的中国高血压防治指南(2005修订版)的诊断标准。所有患者均排除继发性高血压、充血性心力衰竭、甲状腺功能亢进症、肝肾功能不全、脑血管病、糖尿病等。
l.2 方法
将82例原发性高血压确诊门诊患者随机分为谷维素片加硝苯地平缓释片组(治疗组)42例，男26例，女16例；平均年龄(65 ......
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