[摘要] 脑缺血患者入院后血糖通常会大幅度升高，从而导致预后较差。为此，采用胰岛素快速而稳定地降低血糖是很重要的治疗措施。然而，迄今为止，关于胰岛素治疗脑卒中的临床研究还未能得出一个统一明确的治疗方案，而胰岛素的使用也因为其导致低血糖等不良反应而备受限制。在此，本文总结了脑缺血后血糖的变化、胰岛素的保护机制以及目前常用的控制血糖方法，为将来进行临床研究提供参考。

    [关键词] 脑缺血-再灌注损伤；胰岛素；治疗

    [中图分类号] R743.32 [文献标识码]A [文章编号]1673-7210(2010)11(b)-009-03

    Progress on cerebral ischemia-reperfusion injury treated with Insulin

    ZENG Yue

    (Department of Pharmacology, Mansfield Road, University of Oxford, LondonOX1 3QT, UK)

    [Abstract] Patients with acute ischemic stroke frequently test positive for hyperglycemia after admitted into hospital, which is associated with a poor clinical outcome. Thus, to control plasma glucose within an optimal level is essential for treatment. Yet, to date, the clinical researches about this area can not generate a clear and formal protocol. Therefore, we highlight the alterations in blood glucose after ischemia-reperfusion injury, the molecular mechanism of Insulin′s protective actions and the most usually used regimens for glycemic control as reference for any ongoing Insulin-stroke researches. ......