不同剂量米非司酮联合甲氨蝶呤治疗异位妊娠疗效观察(1)
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[摘要] 目的：观察不同剂量米非司酮联合甲氨蝶呤(Methotrexate, MTX)治疗异位妊娠疗效。方法：将90例血β-HCG值在500～3 000 IU/L未破裂输卵管妊娠患者随机分为三组，每组30例。Ⅰ组给予米非司酮50 mg，每日一次，空腹顿服，服后2 h进食，共3 d，Ⅱ组给予米非司酮100 mg(4片)，每日一次，空腹顿服，服后2 h进食共3 d；Ⅲ组给予米非司酮200 mg(8片)，每日一次，空腹顿服，服后2 h进食，共3 d，三组均在第3天予MTX 1 mg/kg单次臀肌注射。结果：随着米非司酮剂量的增加，治疗的成功率明显增高。结论：在联合治疗异位妊娠时，加大米非司酮剂量，可取得满意效果。
[关键词] 异位妊娠；米非司酮；甲氨蝶呤；联合给药
[中图分类号] R714.22[文献标识码]B [文章编号]1673-7210(2010)11(b)-060-02
Efficacy observation on different doses of Mifepristone combined with Metho-trexate in the treatment of ectopic pregnancy
GONG Yinyun
(Department of Gynaecology and Obstetrics, the People′s Hospital of Haimen City, Jiangsu Province, Haimen 226100, China)
[Abstract] Objective: To observe efficacy different doses of Mifepristone combined with Methotrexate in the treatment of ectopic pregnancy. Methods: 90 patients of unruptured tubal pregnancy with serum β-HCG value in the 500-3 000 IU/L were randomly divided into 3 groups, 30 cases in each groups.Ⅰgroup received Mifepristone 50 mg, once a day, fasting Dayton suits, after serving 2 hours of feeding, a total of 3 days; Ⅱgroup received Mifepristone 100 mg (4 tablets), once a day for fasting Dayton suits, after serving 2 hours of feeding a total of 3 days; Ⅲ group received Mifepristone 200 mg (8 tablets) daily a fasting Dayton suits, after serving a total of 3 days 2 hours eating, patients of three groups were given MTX 1 mg/kg single gluteal injection in the first three days. Results: With increasing doses of Mifepristone treatment significantly increased the success rate. Conclusion: Combined treatment of ectopic pregnancy, increasing Mifepristone dose, can lead to satisfactory results.
[Key words] Ectopic pregnancy; Mifepristone; Methotrexate; Combined administration
异位妊娠是妇科常见病，用米非司酮联合甲氨蝶呤(Methotrexate, MTX)治疗异位妊娠已取得临床广泛认可。我院在2006年1月～2009年12月分别采用不同剂量米非司酮联合甲氨蝶呤治疗异位妊娠90例，现将结果报道如下：
1 资料与方法
1.1 一般资料
自2006年1月～2009年12月对我院收治的未破裂输卵管妊娠患者90例行药物保守治疗。诊断依据：病史、血β-HCG值、盆腔阴道B超、妇科检查。
1.2 保守治疗指征
①患者年轻有生育要求。②生命体征平稳，无腹腔内出血或腹腔内少量出血。③B超提示异位妊娠包块≤4 cm；血β-HCG值在500～3 000 IU/L；无肝肾疾病史，肝肾功能正常；外周血白细胞≥4 ......
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