左旋卡尼汀治疗慢性心功能不全疗效观察(1)
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[摘要] 目的：观察左旋卡尼汀对慢性心功能不全的治疗效果。方法：选择慢性心功能不全患者40例，随机分为两组，每组20例。对照组给予常规的心衰治疗，治疗组在此基础上加用左旋卡尼汀3.0 g/d 静点，1次/d，疗程14 d。观察治疗前后心功能状况和药物不良反应。结果：①两组治疗后均有效；②治疗组的总有效率高于对照组(P<0.05)，心功能改善更为显著(P<0.05)，且未见不良反应。结论：慢性心功能不全患者在常规治疗下适量加用左旋卡尼汀能明显改善心功能。
[关键词] 左旋卡尼汀；慢性心功能不全；疗效
[中图分类号] R541.1[文献标识码]B [文章编号]1673-7210(2010)11(b)-063-02
Curative effect observation of L-carnitine in the treatment of patients with chronic heart dysfunction
SONG Guoliang, WAN Zhenying, OUYANG Xianguo, CHEN Qin, XIAO Jiangang
(Department of Cardiovasology, the Third Hospital of Nanchang City, Jiangxi Province, Nanchang 330009, China)
[Abstract] Objective: To observe the effect of L-carnitine on chronic heart dysfunction. Methods: 80 patients with chronic heart dysfunction were divided into two groups randomly, 20 patients in each group. The control group were treated with conventional heart failure therapy. The treatment group were treated with conventional therapy and L-carnitine 3.0 g/d ivgtt, once a day, course of treatment for 14 days. The heart function and the side effects before and after treatment were observed. Results: ①There were effective after treatment in two groups; ②the total effective rate in the treatment group was superior to that in the control group (P<0.05), and the improvement of cardiac function was even more significant than the control group (P<0.05), and no side-effect was observed. Conclusion: Added L-carnitine under conventional treatment is beneficial to improve the cardiac function in the treatment of patients with chronic heart dysfunction.
[Key words] L-carnitine; Chronic heart dysfunction; Curative effect
心力衰竭(心衰)是一种复杂的临床症状群，为各种心脏病的严重阶段，其发病率高，临床症状患者的5年存活率与恶性肿瘤相仿。随着我国社会日趋老龄化，心衰的发病率将继续增长，正成为21世纪最重要的心血管病症[1]。目前针对慢性心功能不全尚无特效治疗方法。近年研究显示，具有心肌细胞保护作用的代谢药物左旋卡尼汀有改善心衰作用[1]，而我科在慢性心功能不全治疗上作了一些探索，在常规用药基础上加用左旋卡尼汀治疗慢性心功能不全患者，取得较好疗效，现报道如下：
1 资料与方法
1.1 一般资料
选择2008年1月～2009年4月在我院心血管科住院患者40例，均符合慢性心功能不全的诊断标准，随机分为两组：治疗组(左旋卡尼汀组)20例，其中，男13例，女7例；平均年龄63.2岁，平均病程(5.2±2.3)年；其中冠心病7例，高血压性心脏病10例，扩张性心肌病2例，风湿性心脏病1例；按NYHA(纽约心功能评级方法)，心功能Ⅲ级9例，心功能Ⅳ级11例。对照组(丹参注射液组)20例 ......
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