抗凝血酶Ⅲ对家兔静脉血栓形成的实验研究(2)
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本研究显示,大剂量的AT-Ⅲ对静脉血栓的形成具有抑制作用,剂量与效应之间呈明显的线性关系,临床上应用AT-Ⅲ可用于预防深静脉血栓形成。
[参考文献]
[1]Eisele B, Lamy M, Thijs LG, et al. Antithrombin Ⅲ in patients with severe sepsis. A randomized, placebo-controlled, double-blind multicenter trial plus a meta-analysis on all randomized, placebo-controlled, double-blind trials with antithrombin Ⅲ in severe sepsis [J]. Intensive Care Med,1998,24(7):663-672.
[2]Inthorn D, Hoffmann JN, Hartl WH, et al. Effect of antithrombin Ⅲ supplementation on inflammatory response in patients with severe sepsis [J]. Shock,1998,10(2):90-96.
[3]Blajchman MA, Auston RC, Fernandez-Rachhubinski F, et al. Molecular basis of inherited human antithrombin deficiency [J]. Blood,1992,80(9):2159-2171.
[4]包承鑫.易栓症的基础与临床[J].血栓研究,1996,1(3):11-14.
[5]Patnaik MM, Moll S. Inherited antithrombin deficiency: a review [J]. Haemophilia,2008,14(6):1229-1239.
[6]Rossie E, Za T, Ciminello A, et al. The risk of symptomatic pulmonary embolism due to proximal deep venous thrombosis differs in patients with different types of inherited thrombophilia [J]. Thromb Haemost,2008,99(6):1030-1034.
[7]黄彬,陈荼,钟武平.深静脉血栓形成患者血浆部分抗凝物质的检测及其临床意义[J].中山医科大学学报,2002,23(2):134-136.
[8]Cuomo O, Pignataro G, Gala R, et al. Antithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia [J]. Stroke,2007,38(12):3272.
(收稿日期:2010-09-20)
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