盐酸法舒地尔治疗缺血性脑卒中疗效观察(1)
 |
| 第1页 |
参见附件(2051KB，2页)。
[摘要] 目的：探讨盐酸法舒地尔在改善缺血性脑卒中患者的神经功能缺损评分中的作用。方法：130例确诊的急性脑卒中患者随机分为治疗组和对照组，在常规治疗的基础上，治疗组给予法舒地尔治疗，对照组给予苦碟子治疗，比较2周后两组患者的神经功能缺损评分情况，并进行临床疗效评价。结果：治疗后两组患者的神经功能缺损评分均较治疗前明显改善，差异有高度统计学意义(P<0.01)，且治疗组患者神经功能缺损评分改善情况较对照组更显著，差异有统计学意义(P<0.05)。结论：盐酸法舒地尔可显著改善脑卒中患者的神经功能缺损评分，改善患者的神经功能恢复和预后，具有较好的安全性。
[关键词] 法舒地尔 缺血性脑卒中 神经功能缺损评分
[中图分类号] R743.3[文献标识码]B [文章编号]1673-7210(2011)02(b)-052-02
Efficacy observation of Fasudil Hydrochloride in treatment of ischemic stroke
KONG Liqin
(Department of Pharmacy, the First Hospital Affiliated of Dalian Medical University, Dalian 116011, China)
[Abstract] Objective: To explore the function of Fasudil Hydrochloride on neurological functional deficit score(NFDS)in ischemic stroke patients. Methods: One hundred and thirty cases with ischemic stroke were randomly and averagely divided into two groups, the treatment group and the control group, on the basis of regular treatments, the treatment group were treated with Fasudil and the control group were treated with Ku diezi, the neurological functional deficit score were compared and the clinical effccts were evaluated in two groups after two weeks. Results: The NFDS in two groups were obviously improved, there was significant differences before and after treatment (P<0.01), and its more significant in the treatment group than that in control group (P<0.05). Conclusion: Fasudil Hydrochloride could improve the NFDS in ischemic stroke patients, improve the recovery of nerve function and prognosis, had a better security.
[Key words]Fasudil; Ischemic stroke; Neurological functional deficit score(NFDS)
缺血性脑卒中是临床常见的高致死和高致残的疾病，传统的治疗主要以溶栓、降纤、抗凝、抗血小板聚集为主，治疗具有一定的风险性。因此，寻找更安全、更有效的治疗药物已成为当务之急，法舒地尔是一种新型的、高效的脑血管保护药物，通过干预脑缺血级联反应改善脑卒中患者的预后，临床应用前景广阔。我院2008年3月～2009年9月应用盐酸法舒地尔治疗急性缺血性脑卒中65例，取得较满意的临床疗效，现总结报道如下：
1 资料与方法
1.1 一般资料
选择2008年3月～2009年9月我院住院治疗的脑卒中患者130例，全部患者均符合卒中的典型临床表现，并经过脑CT或脑MRI检查确诊。其中，男76例，女54例；年龄49～69岁，平均62.8岁；入院时间均于发病后48 h内，且排除脑出血、严重出血倾向、心肺功能不全、年龄大于70岁、严重感染、近期有手术史或外伤史患者。随机平分为治疗组和对照组，两组患者在性别、年龄、神经功能评分、基础疾病等方面具有可比性。
1.2 治疗方法
全部患者均给予甘露醇脱水降颅压、胞二磷胆碱保护脑细胞、肠溶阿司匹林抗血小板聚集，维持水、电解质平衡等综合治疗 ......
您现在查看是摘要介绍页，详见PDF附件(2051KB，2页)。