联合降压治疗老年高血压疗效观察(1)
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[摘要] 目的：探讨联合应用降压药治疗老年高血压的疗效。方法：采取随机、平行分组、对照方法将患者分为三组，甲组40例，单用非洛地平缓释片(钙拮抗剂)10 mg/d；乙组44例，非洛地平缓释片5 mg/d+缬沙坦(血管紧张素Ⅱ受体阻滞剂ARB)80 mg/d；丙组46例，非洛地平缓释片5 mg/d +厄贝沙坦氢氯噻嗪150 mg/d。结果：治疗8周后，丙组收缩压(SBP)和舒张压(DBP)达标率分别为60.9%和95.6%，较甲组SBP达标率(15.0%、80.0%)和乙组(9.1%、68.2%)高，差异有统计学意义(P<0.05或0.01)。甲组总不良反应发生率(27.5%，11/40)与乙组(4.5%，2/44)、丙组(8.7%，4/46)比较，P均<0.05。结论：钙拮抗剂联合ARB复合剂(ARB+小剂量利尿剂)治疗老年高血压疗效理想，且不良反应低。
[关键词] 高血压抗高血压药物；厄贝沙坦；利尿药
[中图分类号] R544.1[文献标识码]B [文章编号]1673-7210(2011)02(c)-061-02
Effect observation of treating age patients with hypertension by multi-antihypertensive drugs
HAO Dejing1, LUO Li2, TANG Chunyan1, QU Jianhua3
[1.Emergency Center, No. 4 Clinical Hospital Attached to Jilin University (FAW Hospital),Changchun 130011,China;2.ICU, No. 4 Clinical Hospital Attached to Jilin University (FAW Hospital),Changchun 130011,China; 3.Pharmacy Department, No. 4 Clinical Hospital Attached to Jilin University (FAW Hospital),Changchun 130011,China]
[Abstract] Objective: To discuss the effect of treating age patients with hypertension by using multi-antihypertensive drugs. Methods: The patients were divided into three groups randomly. There were 40 patients in group A;each one in this group took the single drug felodipine(calcium antagonist)10 mg/d. There were 44 patients in group B;each one in this group took the drug felodipine(calcium antagonist)5 mg/d and valsartan(angiotensinⅡreceptor blocker,ARB)80 mg/d. There were 46 patients in group C;each one in this group took the drug felodipine(calcium antagonist)5 mg/d, Irbesartan and hydrochlorothiazide 150 mg/d. Results: After the treatment of 8 weeks, the patients′ SBP in group C was lower than 140 mm Hg and DBP was lower than 90 mm Hg. The ideal rate was 60.9% and 95.6% respectively. They were higher than the rates of SBP and DBP in group A (15.0%, 80.0%)and that in Group B(9.1%, 68.2%), all P<0.05. Adverse reaction rates in group B(4 ......
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