预注曲马多用于抑制全麻患者苏醒期不良反应的临床观察(1)
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[摘要] 目的：观察曲马多抑制全麻患者苏醒期不良反应的效果。方法：将100例患者随机分为A、B两组，每组50例，A组(观察组)，在手术结束前预注曲马多2 mg/kg，B组(对照组)，在手术结束前不做任何处理。观察两组患者在苏醒前和苏醒期的收缩压(SBP)、舒张压(DBP)、心率(HR)的变化及两组患者在苏醒期寒战、躁动的发生率。结果：与B组苏醒前和A组相比，B组患者苏醒期SBP、DBP、HR变化差异有统计学意义(P<0.05)，A组患者苏醒前与苏醒期SBP、DBP、HR变化比较差异无统计学意义(P>0.05)，A组患者苏醒期寒战、躁动的发生率明显少于B组(P<0.05)。结论：全麻患者在苏醒前预注2 mg/kg曲马多可有效地预防苏醒期不良反应的发生。
[关键词] 曲马多 苏醒期 不良反应
[中图分类号] R614.2+1[文献标识码] B[文章编号] 1673-7210(2011)02(c)-067-02
Clinical observation of preinjecting Tramadol in the contain of adverse reactions during awakening period of general anesthesia
SHAO Zhaojun, WANG Yinghu, HE Wei
(Department of Anesthesiology, Tianjin Binhai New Area Hangu Hospital, Tianjin 300480, China)
[Abstract] Objective: To investigate the preventive effect of preinjecting Tramadol on the adverse reactions in general anesthesia during awakening period. Methods: 100 cases undergoing general surgery were randomly divided into group A (observation group) and group B (control group) with 50 cases in each group. Tramadol 2 mg/kg was administered intravenously to the patients in the observation group, but no medicine was given to the control group. SBP, DBP and HR of two groups before and during awakening period and the incidence rate of cold shivers and agitate during awaking period were observed. Results: SBP, DBP and HR during awaking period of group B increased significantly than those of group A and before group B awaking period (P<0.05). SBP, DBP and HR during awaking period of the group A had no significant change than that of group B before awaking period (P>0.05). The incidence rate of cold shivers and agitate during awaking period in group A obviously lower than those in Group B (P<0.05). Conclusion: The preinjecting Tramadol with 2 mg/kg can effectively prevent the adverse reactions in general anesthesia during awakening period.
[Key words] Tramadol; Awaking period; Adverse reactions
全麻患者苏醒期常引起血压升高、心率增快及寒战、躁动、疼痛等不良反应[1]，这对有高血压、冠心病、脑血管病者可能导致心脑血管意外等严重并发症 ......
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