TUM2-PK\TPS\CEA联合检测在肺癌中的临床价值(1)
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[摘要] 目的：探讨肺癌患者血清中TPS、CEA和血浆中TU M2-PK的临床应用价值。方法：采用ELISA法分别检测60例肺癌患者，54例良性肺部疾病和40例健康成人血清中TPS、CEA和血浆中TU M2-PK水平，并对28例肺癌患者进行术后1个月和3个月的随访检测。结果：肺癌组TU M2-PK、TPS、CEA水平明显高于良性肺疾病组和健康对照组(P<0.05)。3种肿瘤标志物单项检测时，TPS的敏感性(78.3%)最高，TU M2-PK的准确性(83.3%)最高；多项联合检测时，以TU M2-PK+TPS+CEA组合获得的敏感性(98.3%)和准确性(89.0%)最高，但特异性(83.0%)有所降低。3种肿瘤标志物水平随临床分期(TNM)增加而升高，Ⅰ、Ⅱ期和Ⅲ、Ⅳ期比较，TPS、CEA、TU M2-PK差异有统计学意义(P<0.05)。手术治疗后，3种肿瘤标志物均较术前明显下降。结论：3种肿瘤标志物在肺癌的诊断治疗中，具有一定的临床应用价值。TU M2-PK+TPS+CEA组合可明显提高肺癌诊断的敏感性和准确性。
[关键词] 肿瘤标志物；肺肿瘤；组织多肽特异性抗原；癌胚抗原；肿瘤M2型丙酮酸激酶
[中图分类号] R734.2[文献标识码]A [文章编号]1673-7210(2011)04(a)-020-03
Clinical value of combined determination of TU M2-PK, TPS, CEA in the patients with lung cancer
GUO Shangde1, WANG Zhongyi2, LIU Hong1, LIU Chunyun1, ZHANG Li1
1.Institute of Respiratory and Occupational Disease, Shanxi Datong University, Datong 037009, China; 2.Chest Surgery of the No.5 People′s Hospital of Datong City, Datong 037006, China
[Abstract] Objective: To investigate the clinical value of serum TPS, CEA and plasma TU M2-PK in lung cancer patients. Methods: The concentration of TPS, CEA and TU M2-PK were detected by ELISA in 60 lung cancer patients, 54 benign lung disease patients and 40 healthy people. Moreover follow-up visit was undertaken at one month and three months after surgery for lung cancer patients. Results: The level of TPS，CEA and TU M2-PK were significantly higher in lung cancer than those in benign lung disease and health controls (P<0.05). TPS showed the highest sensitivity (78.3%) and TU M2-PK showed the highest accuracy (83.8%) in single tumor marker detection, and TU M2-PK+TPS+CEA showed the highest sensitivity (98.3%) and accuracy (89.0%)， but lower specificity (83.0%) in combined tumor marker detection for diagnosis of lung cancer. The level of TPS, CEA, TU M2-PK in stage Ⅲ and stage Ⅳ were evidently higher than those in stage I,Ⅱ. After operation, a marked decreasing in these values was observed ......
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