川芎嗪注射液联合甲钴胺治疗糖尿病周围神经病变疗效观察(1)
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[摘要] 目的：观察川芎嗪注射液联合甲钴胺对糖尿病周围神经病变的疗效。方法：将60例糖尿病周围神经病变患者随机分为治疗组和对照组，两组均给于饮食控制及糖尿病基础治疗，治疗组用磷酸川芎嗪注射液，同时口服甲钴胺片0.5 mg，每日3次，4周为1个疗程。对照组口服甲钴胺0.5 mg，每日3次，共4周。结果：治疗组总有效率为93.3%，对照组总有效率为66.7%，两组治疗结果比较差异有高度统计学意义(χ2=6.67，P<0.01)。结论：川芎嗪注射液联合甲钴胺能明显缓解糖尿病周围神经病变患者临床症状，提高神经传导速度，治疗糖尿病周围神经病变疗效显著。
[关键词] 糖尿病周围神经病变；川芎嗪注射液；甲钴胺
[中图分类号] R587.2 [文献标识码]B[文章编号]1673-7210(2011)04(a)-071-02
Clinical observation of Ligustrazine Injection combined with Mecobalamin in treating diabetic peripheral neuropathy
CAO Meng, ZHANG Qinggui, WANG Tao, CHEN Xuehui
Department of Endocrinology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China
[Abstract] Objective: To observe the curative effect of Ligustrazine Injection combined with Mecobalamin in treating diabetic peripheral neuropathy. Methods: Sixty patients with type 2 diabetes and diabetic peripheral neuropathy were randomly divided into treatment group and control group, two groups were given alimentary control and diabetes basis therapy. Patients in treatment group were treated with Ligustrazine Phosphate and Mecobalamin for four weeks, and the patients in control group were treated with Mecobalamin for four weeks. Results: The total effective rate in treatment group was 93.3%, and in control group was 66.7%, the comparison of treatment outcome between two groups had significant difference (χ2=6.67，P<0.01). Conclusion: Ligustrazine Injection combined with Mecobalamin can obviously release clinical symptoms in patients with diabetic peripheral neuropathy, improve nerve conductive velocity, has evident effects in treating diabetic peripheral neuropathy.
[Key words] Diabetic peripheral neuropathy; Ligustrazine Injection; Mecobalamin
糖尿病周围神经病变(diabetic peripheral neuropathy，DPN)是糖尿病常见慢性并发症，发生率为47%～90%，主要表现为双上肢或双下肢程度及范围不同的疼痛、麻木及感觉减退等。其发病机制尚未完全清楚，目前仍缺乏疗效显著的根治手段。虽然积极的血糖控制是预防糖尿病神经病变发生的关键，但却很难逆转已存在的病变。笔者在常规治疗的基础上以川芎嗪联合甲钻胺治疗60例糖尿病周围神经病变患者，取得了良好疗效，现报道如下：
1 资料与方法
1.1 一般资料
选取2009年10月～2010年10月在我科住院的伴DPN的2型糖尿病患者60例，均符合世界卫生组织(WHO)1999年公布的糖尿病诊断标准[1]，符合糖尿病周围神经病变国内常用标准[2]：肢体麻木、疼痛、蚁行感、肌无力等症状；深浅感觉明显减退(10 g尼龙丝检查、40 g细针痛觉检查、Bio-thesiometer) ......
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