不同梗死面积急性脑梗死患者D-二聚体含量动态观察(1)
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[摘要] 目的：观察不同面积急性脑梗死患者血浆D-二聚体含量的动态变化，并探讨其临床意义。方法：将入选的100例急性脑梗死患者按不同梗死面积分成大梗死、中梗死、小梗死、腔隙性梗死四组，其中大梗死组15例，中梗死组10例，小梗死组14例，腔隙性梗死组61例。50例选自我院健康体检者，于清晨空腹采静脉血1次测定血浆D-二聚体含量，作为正常对照组。各观察组在发病48 h内测定初次的血浆D-二聚体含量，治疗到2周时复查一次，各组结果先与对照组比较，再相互比较。结果：四组急性脑梗死患者初次血浆D-二聚体含量均高于正常对照组(P<0.05)；四组初次血浆D-二聚体含量相互比较，差异无统计学意义(P>0.05)；治疗2周时复查，大梗死、中梗死、小梗死、腔隙性梗死四组血浆D-二聚体含量分别为(334.20±59.68) μg/L、(186.40±27.72) μg/L、(112.65±22.56) μg/L、(75.61±9.82) μg/L，均有下降(P<0.05)。结论：脑梗死患者发病48 h内血浆D-二聚体的含量升高，但不同梗死面积各组间无明显差异；治疗到2周时四组的血浆D-二聚体含量均有下降并出现差异。这种变化有助于评价脑梗死进展及复发的风险，对急性脑梗死的抗栓治疗有指导意义。
[关键词] 脑梗死；D-二聚体；纤维蛋白原
[中图分类号] R743[文献标识码]A [文章编号]1673-7210(2011)04(b)-013-03
Clinical observation for the dynamic changes of plasma D-dimer in the patients with acute cerebral infarction grouped by infarct size
LIANG Yan, WU Yong, LIANG Hanzhou, HUANG Dandan
Department of Internal Neurology, the People′s Hospital of Gaozhou City, Guangdong Province, Gaozhou 525200, China
[Abstract] Objective: To observe the dynamic changes of plasma D-dimer at acute stage of cerebral infarction, and approach the relationship between the level of D-dimer and the different infarction size. Methods: 100 patients with acute ischemic stroke were divided into 4 groups (large-size, medium-size, small-size, lacunar infarcts) by CT/MR classifications. 15 cases in the large-size infarcts group, 10 cases in the medium-size infarcts group, 14 cases in the small-size infarcts group, 61 cases in the lacunar infarcts group. Selected 50 healthy physical examinees in our hospital, the plasma D-dimer specimens were gathered as the normal control group before eating food in the morning. The plasma D-dimer specimens in 4 patients groups were gathered within 48 hours after onset and at the 2nd week after treatment. The data of 4 groups compared with that of control group, and then compared each other. Results: The plasma D-dimer specimens increased after acute cerebral infarction, and the data was significantly higher than that in the control group (P<0 ......
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