经皮穿刺动脉导管药盒系统药物灌注治疗下肢动脉硬化闭塞症的研究(1)
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[摘要] 目的：探讨经皮动脉穿刺导管药盒系统药物灌注治疗下肢动脉硬化闭塞症的临床疗效。方法：60例下肢动脉硬化闭塞症患者，随机分为治疗组、对照组，每组各30例。治疗组患者行经皮穿刺动脉药盒系统埋植术，并经动脉导管系统行前列地尔注射液、丹参注射液灌注治疗；对照组静脉滴注上述药物。14 d为1个疗程，共治疗2个疗程。治疗前后测定踝臂指数(ABI)。结果：治疗组有效28例，无效2例，总有效率为93.33%；对照组有效16例，无效14例，总有效率为53.33%；两组总有效率差异明显(P=0.000)。两组治疗前ABI比较无差异，两组治疗后ABI均较治疗前好转(均P<0.05)，但治疗组明显优于对照组(P<0.01)。结论：经皮穿刺动脉动脉导管系统药物灌注治疗下肢动脉硬化闭塞症作用明显，能有效改善下肢血液循环，疗效满意。
[关键词] 下肢动脉硬化闭塞症；导管药盒系统；治疗；踝臂指数
[中图分类号] R543.5 [文献标识码] B [文章编号] 1673-7210(2011)06(c)-104-02
Study of percutaneous intra-arterial femoral port-catheter system for treatment on arteriosclerosis obliterans
WANG Dongsheng, WANG Chenggang, LU Ying, LIU Ming, LIU Haiyang
Department of Intervention, Coal General Hospital, Beijing 100028, China
[Abstract] Objective: To investigate the clinical efficacy of percutaneous intra-arterial femoral port-catheter system (PCS) for treatment on arteriosclerosis obliterans. Methods: 60 patients with arteriosclerosis obliterans were divided into treatment group and control group; the treatment group were treated by using alprostadil injection and salvia miltiorrhiza injection via PCS. The control group were treated by using the same medication by intravenous infusion. The patients were treated in 4 weeks. Ankle brachial indexs (ABI) were examined before and after treament. Results: The effective percentage of treatment group was 93.33%, the same of control group was 53.33%. There were significantly differences between treatment group and control group (P=0.000). There were significant differences of the ABI between treatment group and control group after treatment (P<0.01). Conclusion: The technique of percutaneous intra-arterial femoral port-catheter system implatation for interventional treatment for arteriosclerosis obliterans is available.
[Key words] Arteriosclerosis obliterans; Port-cathetersystem (PCS); Interventional treatment; Ankle brachial index (ABI)
当今社会，随着我国人民生活水平提高，饮食习惯的改变，下肢动脉硬化闭塞症(arteriosclerosis obliterans，ASO)发病率逐年增加[1]。其临床主要表现为下肢缺血性疼痛、间歇性跛行及肢体坏死，严重影响患者生活质量。由于此类患者多为高龄，多伴有多种基础疾病，在以往临床治疗过程中易出现严重的并发症而导致疗效差甚至患者死亡[2]。因此，选择安全有效的治疗方法成为治疗ASO目前研究的重点。经皮穿刺动脉导管药盒系统行药物灌注是一种微创治疗方法，在临床工作中广泛应用。我科自2007年6月～2010年5月采用该技术治疗ASO患者60例 ......
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