C-反应蛋白与肌钙蛋白I在急性冠状动脉综合征中检测的临床意义研究(1)
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[作者简介] 陈广新(1969-)，男，大专学历，主管检验师，主要从事医学检验工作。
[摘要] 目的：探讨C-反应蛋白(CRP)与肌钙蛋白I(cTnI)在急性冠状动脉综合征(ACS)中检测的临床意义。方法：分别检测31例不稳定性心绞痛(UAP)患者、34例稳定性心绞痛(SAP)患者、24例急性心肌梗死(AMI)或因心脏病猝死的患者，症状发作后6～8 h血清CRP和cTnI的含量变化。并与健康对照组比较分析。同时分析血清CRP和cTnI含量的高低与心脏事件发生率的相关性。结果：UAP组、SAP组、AMI组血清CRP和cTnI的含量均高于健康对照组，且含量越高，心脏事件的发生率越高。其含量高低顺序为AMI组>UAP组>SAP组。AMI组和UAP组患者的血清CRP和cTnI含量明显高于健康对照组，且差异具有统计学意义(P<0.05)。SAP组血清CRP和cTnI的含量与健康对照组相比，差异无统计学意义(P>0.05)。结论：CRP与cTnI联合检测对于ACS的诊断及预后判断具有更高的临床意义。
[关键词] C-反应蛋白；肌钙蛋白I；急性冠状动脉综合征
[中图分类号] R541[文献标识码] B[文章编号] 1673-7210(2011)07(c)-095-03
The clinical significance of detecting C-reactive protein and troponin I in acute coronary syndrome
CHEN Guangxin, LI Sumei, WU Xiaomei, SU Xuefei
Clinical Laboratory of People's Hospital of Huadu District in Guangzhou City, Guangdong Province, Guangzhou 510800, China
[Abstract] Objective: To discuss the clinical significance of detecting C-reactive protein (CRP) and troponinI (cTnI) in patients with acute coronary syndrome (ACS). Methods: To detect serum CRP and cTnI variation in 31 cases of unstable angina pectoris (UAP) patients, 34 cases of stable angina patients (SAP), 24 cases of acute myocardial infarction (AMI) patients or sudden death from heart disease in 6-8 h after symptoms broken out; then comparied with control group and analyze correlation of CRP and cTnI with the incidence of cardiac events. Results: cTnI and CRP level of UAP group, SAP group, AMI group were higher than control group, and the higher of the content, the higher of the heart attack incidence. Its content discretion order was UAP group>AMI group>SAP group. cTnI and CRP level of UAP group and AMI group were higher than control group, there were significance differerences between AMI group and CRP group(P<0.05), then there were no significance difference between SAP group and control group (P>0.05). Conclusion:CRP and cTnI joint detection have higher clinical significance for diagnosis and prognosis of ACS.
[Key words] C-reactive protein; Aroponin I; Acute coronary syndrome
急性心肌梗死(AMI)和不稳定性心绞痛(UAP)是急性冠状动脉综合征(ACS)的主要临床表现。主要发病过程为冠状动脉中出现粥样斑块的不稳定性损伤，如破裂、表面破损、出现裂纹等。粥样斑块的损伤继发血管出血甚至血栓的形成，造成冠状动脉的部分或完全堵塞，炎症加剧，因此，针对冠状动脉粥样斑块的损伤检测对于ACS的诊断及预后具有较高的临床价值。C-反应蛋白(CRP)是炎症反应发生的急性时相蛋白 ......
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