左氧氟沙星注射液治疗泌尿系感染疗效分析(1)
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[摘要] 目的：在PK/PD参数理论指导下，观察左氧氟沙星静滴每日1次和每日2次治疗泌尿系感染的疗效。方法：选取86例泌尿系感染患者，随机分为治疗组和对照组，每组43例，治疗组用左氧氟沙星400 mg，静脉滴注，1次/d，对照组用左氧氟沙星200 mg，静脉滴注，2次/d。结果：用药3 d后两组血和尿中白细胞数、血中性粒细胞数及体温>37℃的病例数比较，差异有统计学意义(P<0.05)。其中，治疗组有效率为95.3%(41/43)，对照组为83.7%(36/43)，两组有效率比较，差异有统计学意义(P<0.05)。结论：左氧氟沙星治疗泌尿系统感染，静滴每日1次给药疗效优于静滴每日2次。
[关键词] 左氧氟沙星；泌尿系感染；疗效；PK/PD参数
[中图分类号] R691.3[文献标识码]A [文章编号]1673-7210(2011)08(a)-082-02
Curative efficacy analysis of Levofloxacin Injection in urinary system infection
WEI Xiaojing1, FAN Xiaodong1, QIAN Shaohong2
1.Department of Pharmacy, China Railway Shanhaiguan Bridge Group Hospital of Qinhuangdao City, Hebei Province, Qinhuangdao 066200, China; 2.Deptment of Endocrinology, Worker′s Hospital of Qinhuangdao City, Hebei Province, Qinhuangdao 066200, China
[Abstract] Objective: To observe the clinical efficiency of Levofloxacin ivgtt qd and bid in urinary system infection under the guide of PK/PD parameters theory. Methods: 86 cases of patients with urinary system infection were randomly divided into two groups, 43 cases of patients in treatment group with Levofloxacin 400 mg ivgtt qd; 43 cases of patients in control group with Levofloxacin 200 mg ivgtt bid. Results: The counting of WBC in urine and blood , neutrocyte in blood and the case of patients whose temperature over 37℃ after 3 days using of Levofloxacin, were significantly different between the two groups (P<0.05). The efficiency rate of treatment group was 95.3% and 83.7% in control group. Conclusion: Levofloxacin ivgtt qd has a better curative effect than ivgtt bid in patients of urinary tract infections.
[Key words] Levofloxacin; Urinary tract infections; Therapeutic effect; PK/PD parameters
近年来，随着药效动力学和药代动力学的深入研究，PK/PD参数理论逐渐被人们接受，PK/PD参数理论在指导抗菌药物的临床应用方面起了重要作用。本文在PK/PD参数理论指导下，观察左氧氟沙星静滴每日1次和每日2次的疗效，从而指导临床更合理用药。
1 资料与方法
1.1 一般资料
选取2010年1月～2011年3月本院收治的泌尿系感染患者86例，体重≤标准体重±20%，尿白细胞计数>20个/HP，血常规白细胞计数>12×109 /L；体温38℃。随机分为两组，每组43例。治疗组男28例，女15例；年龄为(52±17)岁；体重为(65.8±13.6)kg；平均体温(38.6±0.5)℃；其中，膀胱炎31例，肾盂肾炎12例。对照组男24例，女19例；年龄为(54±16)岁；体重为(66.7±14.3)kg；平均体温(38.5±0.52)℃；其中，膀胱炎27例，肾盂肾炎16例。两组在年龄、性别、体重和临床症状等方面差异无统计学意义(P>0 ......
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