舒利迭吸入对中重度COPD患者血气及肺功能影响(1)
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[摘要] 目的：探讨舒利迭吸入对中重度慢性阻塞性肺疾病(COPD)患者血气及肺功能的影响。方法：将76例稳定期中重度慢性阻塞性肺疾病患者随机分为观察组和对照组各38例。两组患者均予以COPD常规治疗，包括止咳、平喘、抗感染等对症支持治疗。对照组予以茶碱缓释片口服，并酌情给予沙丁胺醇气雾剂治疗；观察组给予以舒利迭吸入。两组疗程均为8周。结果：两组患者治疗后用力肺活量(FVC)、1 s用力呼气容积(FEV1)及1 s用力呼气容积占用力肺活量百分比(FEV1/FVC%)明显优于治疗前，治疗前后比较，差异有统计学意义(P<0.05或P<0.01)；治疗后观察组FVC、FEV1、FEV1/FVC%改善情况与对照组比较，差异均有统计学意义(P<0.05)；两组患者治疗后血气指标较治疗前明显改善，前后比较，差异有统计学意义(P<0.05)；观察组治疗后血气指标明显优于与对照组，两组比较差异有统计学意义(P<0.05)。结论：舒利迭吸入治疗可减慢COPD患者FEV1的下降速率，改善肺功能，增加运动耐量，减轻呼吸困难，提高患者的生活质量。
[关键词] 慢性阻塞性肺疾病；舒利迭；血气；肺功能
[中图分类号] R563[文献标识码]A[文章编号]1673-7210(2011)08(a)-084-02
Influence of Seretide intake on arterial blood gas and pulmonary function of medium and severe COPD patients
CHEN Yakuan, SUN Jianxin, GUO Hanqiang, LI Shiwen, ZHANG Haiqing
The Second People′s Hospital of Zhaoqing City, Guangdong Province, Zhaoqing 526060, China
[Abstract] Objective: To investigate influence of Seretide intake on arterial blood gas and pulmonary function of medium and severe COPD patients. Methods: 76 cases of moderate or severe chronic obstructive pulmonary disease (COPD) patients in stationary phase were randomly divided into observation group and control group respectively. Patients of each group were given conventional treatment which include controlling cough, antiasthmatic treatment, anti-infection, and supporting therapy. Patients in control group were given Theophylline sustained-release tablets, and Salbutamol Aerosol according to circumstances; The observation group was given Seretide inhalation. Treatment course of two groups were both 8 weeks. Results: After treatment, forced vital capacities (FVC), forced expiratory volume in 1 second (FEV1) and the percentage of forced expiratory volume in 1 second in forced vital capacities (FEV1/FVC%) of patients in two groups were much better than before, the differences had statistical significance(P<0.05 or P<0.01); After treatment, improvement of FVC, FEV1, FEV1/FVC% of observation group were more obvious than control group (P<0.05); blood gas indexes of two groups had significant improvements, the differences before and after treatment had statistical significance (P<0 ......
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