武汉地区腹泻患儿轮状病毒感染的检测分析(1)
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[作者简介] 张光萍(1962-)，女，湖北人，本科，主管技师，主要从事临床检验工作。
[摘要] 目的：了解武汉地区腹泻患儿轮状病毒(RV)感染特点，为临床诊治提供参考依据。方法：采用胶体金免疫层析法对腹泻患儿粪便标本进行RV检测，分析结果。结果：2 037例腹泻患儿粪便标本中RV阳性率为29.5%(601/2 037)，<1个月、1～5个月、6～11个月、1～2岁、>2岁且≤3岁、>3岁且≤5岁年龄组患儿中，感染率分别为21.55%(25/116)、18.51%(77/416)、32.79%(319/973)、35.32%(160/453)、30.61%(15/49)、16.67%(5/30)；RV感染全年均可发生，高峰期在9～11月，检出率分别为34.29%、47.47%和39.67%。结论：武汉地区腹泻患儿RV感染普遍，以6个月～2岁年龄组最多，新生儿感染情况不容忽视，流行高峰期应尽早对腹泻患儿进行RV检测，采取积极有效的预防措施，并及时进行合理治疗，防止疾病传播。
[关键词] 武汉地区；腹泻患儿；轮状病毒；胶体金免疫层析法
[中图分类号] R725.7[文献标识码] C[文章编号]1673-7210(2011)08(a)-139-02
Detection analysis of rotavirus infection in children with diarrhea in Wuhan
ZHANG Guangping, JIANG Lian, WANG Xiaomei, LIU Xiuzhen
Department of Clinical Laboratories of Wuhan Medical and Health Center for Women and Children, Hubei Province, Wuhan 430016, China
[Abstract] Objective: To investigate the status of rotavirus(RV) infection among children with diarrhea in Wuhan. Methods: Stool samples were collected from hospitalized children with diarrhea. The colloidal gold immunochromatography was used to detect RV and then the results were analyzed. Results: 2 037 cases of patients were detected, RV in 610 cases were positive (29.5%), infection rate of <1 month, 1-5 months, 6-11 months, 1-2 years old, >2 and ≤3 years old, >3 and ≤5 years old age group were 21.55% (25/116), 18.51% (77/416), 32.79% (319/973), 35.32% (160/453), 30.61% (15/49) and 16.67% (5/30) respectively. RV infection occured throughout the year, but the peak point of RV diarrhea was appeared in September to November. The positive rate was 34.29%, 47.47% and 39.67% respectively. Conclusion: Rotavirus infection in children with diarrhea is a universal problem in Wuhan. The susceptible age is 6 months-2 years old and the newborn infection can not be ignored. The infants with diarrhea should be detected RV antigen as soon as possible in the peak of RV prevalence and given effective precautions and rational treatment, so as to prevent transmission.
[Key words] Wuhan region; Children with diarrhea; Rotavirus; Colloidal gold immunochromatography ......
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