早期肾综合征出血热凝血功能检测结果分析及其临床意义(1)
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[摘要] 目的：通过检测早期HFRS患者凝血功能变化，分析其临床意义。方法：实验组为我院收治的HFRS患者65例，发病时间1～5 d。对照组为健康人群65例。检测受试者的凝血功能，对比分析检测结果。结果：实验组中血小板(PLT)和纤维蛋白原(Fib)均降低，与病情程度呈反比例关系，各组间有高度统计学意义(P<0.01)；凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)均延长，与病情程度呈正比例关系，各组间有统计学意义(P<0.05)。DIC总发生率为21.5%，其发生率与病情程度成正比例关系。总病死率为3.1%。结论：早期HFRS凝血功能检测，可以预示病情的严重程度。
[关键词] 肾综合征出血热；凝血功能；早期；分析
[中图分类号] R512.8[文献标识码]B[文章编号]1673-7210(2011)08(a)-160-02
Inspection result analysis and clinical significance of coagulative fuction in early hemorrhagic fever with renal syndrome patients
LI Zhuo, CAO Bingsheng, LIU Qian
Department of Ultrasound, the 309th Hospital of PLA, Beijing 100091, China
[Abstract] Objective: To detect coagulative fuction in the early period of hemorrhagic fever with renal syndrome (HFRS), and analyze its clinical significance. Methods: Coagulative fuction of the experiment group included 65 cases of HFRS patients in our hospital, with the incidence time was from 1 to 5 days and the control group included 65 cases of healthy people was detected, and the results were analyzed. Results: Fib and PLT were lower in the experiment group, and had an inversely proportional relationship with the severity of disease. Difference between the groups was statistically significant (P<0.01). PT and APTT in the experiment group were prolonged, and had a positively proportional relationship with the severity of disease. There were significant differences between two groups (P<0.05). Incidence of DIC was positively proportional to severity of disease with the total incidence of DIC was 21.5%. The total mortality rate was 3.1%. Conclusion: Early detecting coagulative function in HFRS pateints can predict the severity of the disease.
[Key words] Hemorrhagic fever with renal syndrome; Coagulative fuction; Analysis; Early period
肾综合征出血热(HFRS)是一种自然疫源性疾病，具有分布广，病情危重，病死率高等特点[1]，病理原因为全身小血管内微血栓所致。病情进展激活内凝系统，促进纤溶亢进，极易发生弥散性血管内凝血(DIC)。死亡原因多为广泛和严重的出血[2]。凝血功能项目检测是判断出血性疾病类型的主要诊断方法。本文通过对比研究，分析早期HFRS凝血功能的变化，并探索凝血功能检测在早期HFRS诊治中的临床意义。
1 资料与方法
1.1 一般资料
选取2006年5月～2011年6月我院收治的HFRS患者65例 ......
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