低分子肝素联合前列地尔治疗高原心脏病顽固性心衰的临床疗效观察(1)
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[摘要] 目的：观察低分子肝素联合前列地尔治疗高原心脏病顽固性心衰患者的疗效。方法：将64例高原心脏病患者分为对照组和治疗组，对照组30例，为常规治疗；治疗组34例，在常规治疗的基础上给予低分子肝素钠、前列地尔治疗。观察两组治疗前后临床疗效，利尿剂使用剂量，动脉血气、右室流出道内径、右心室内径、右肺动脉内径以及肺动脉收缩压(PASP)、NT-proBNP的变化。结果：治疗组较对照组疗效显现更快，PaO2 、右室流出道内径、右心室内径、右肺动脉内径以及PASP、NT-proBNP明显改善，利尿剂用量更少，差异有统计学意义(P<0.05或P<0.01)。治疗组有效率达91.2%，对照组有效率为73.3%，差异有统计学意义(P<0.05)。结论：前列地尔联合低分子肝素治疗高原心脏病顽固性心力衰竭患者能显著降低肺动脉压力，改善心功能，为安全有效的治疗方法。
[关键词] 高原性心脏病；顽固性心衰；低分子肝素；前列地尔；低氧性肺动脉高压
[中图分类号] R541 [文献标识码] A [文章编号] 1673-7210(2011)11(a)-064-03
Clinical evaluation of the combination of low-molecular heparin and lipo-prostagland E1 in the treatment of high altitude heart disease with refractory heart failure
DENG Cuidong1, LI Fang'an2, ZHAO Mao2
1.Department of Geriatrics, the 4th People′s Hospital of Zigong City, Sichuan Province, Zigong 643000, China;2.Department of Cardiology, the People′s Hospital of Aba, Sichuan Province, Aba 624000, China
[Abstract] Objective: To study the effect of the combination of low-molecular heparin and lipo-prostagland E1 in the treatment of high altitude heart disease with refractory heart failure. Methods: 64 patients with altitude heart disease with refractory heart failure were divided into a treatment group (34) and a control group(30), the 30 patients in the control group received normal therapy, such as anti-infection, oxygen therapy, ventilation improvement, heart stimulation, diuresis and so on, the 34 patients in the treatment group were administered with the combination of low-molecular heparin and lipo-prostagland E1 on base of normal therapy, then observed the clinical effect before and after treatment, the dose of used diuresis, the change in artery blood gas analysis and pulmonary arterial systolic pressure, NT-proBNP and diameter of RVOT, RV and RPA. Results: The appearance of the curative effect of the treatment group was faster than that of the control group; there was a significant improvement in artery blood gas analysis, pulmonary arterial systolic pressure, NT-proBNP and the diameter of RVOT, RV, RPA; the dose of used diuresis was less(P<0 ......
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