乳腺癌术后患者血清癌胚抗原,糖类抗原15-3与99Tcm-亚甲基二膦酸盐全身骨扫描结果分析(1)
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[摘要] 目的：探讨癌胚抗原(CEA)与糖类抗原15-3(CA15-3)联合检测对99Tcm-亚甲基二膦酸盐(MDP)全身骨扫描诊断乳腺癌骨转移特异性价值的影响。方法：对78例乳腺癌患者分别进行CEA、CA15-3检测及99Tcm-MDP全身骨扫描检查，并选择30例健康人群者作为对照组进行比较。结果：全身骨转移组CEA与CA15-3检测结果较对照组显著上升(P<0.01)。1～3处放射性浓聚灶组CEA与CA15-3检测结果均较对照组上升(P<0.05、P<0.01)。无骨转移组CEA与CA15-3检测结果与对照组比较，差异无统计学意义(P>0.05)。各组CEA与CA15-3检测阳性率比较，对照组均为0，全身骨转移组CEA与CA15-3检测阳性率(65.6%和68.8%)与对照组比较，差异有高度统计学意义(P<0.01)；1～3处放射性浓聚灶组CEA与CA15-3检测阳性率(29.2%和16.7%)与对照组比较，差异有统计学意义(P<0.05、P<0.01)；无骨转移组CEA与CA15-3检测结果检测阳性率(9.1%和4.5%)与对照组比较，差异无统计学意义(P>0.05)。结论：在行全身骨显像的同时，联合检测CEA、CA15-3水平能提高骨显像的特异性，减少误诊，特别是病灶孤立或较少时意义更大。
[关键词] 乳腺癌；全身骨扫描；癌胚抗原；糖类抗原15-3
[中图分类号] R737.9 [文献标识码] B [文章编号] 1673-7210(2011)11(a)-112-02
Analysis of serum CEA, CA15-3 levels and 99Tcm-MDP whole body bone scanning breast cancer after operation
ZENG Xiaoming
Department of Nuclear Medicine, the First People′s Hospital of Taicang City, Jiangsu Province, Taicang 215400, China
[Abstract] Objective: To explore the value of combined detection of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) for diagnosis of breast cancer by 99Tcm-MDP (MDP) whole body bone scanning. Methods: 78 cases of patients with breast cancer received 99Tcm-MDP for whole body bone scanning and CEA, CA15-3 detection. And 30 cases of health people were selected as control group. Results: The results of CEA, CA15-3 in the systemic bone metastasis group increased compared with control group (P<0.01). The results of CEA, CA15-3 in the 1-3 parts of radioactive concentration group increased compared with control group (P<0.05, P<0.01). There was no significant difference about the results of CEA, CA15-3 between the non-systemic bone metastasis group and control group (P>0.05). The positive rates of CEA, CA15-3 were compared in the groups, it was 0 in the control group, the positive rates of the systemic bone metastasis group was 65 ......
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