组织因子及组织因子途径抑制物在急性脑血管意外并发神经源性肺水肿中的变化研究(1)
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[摘要] 目的：探讨急性脑血管意外并发神经源性肺水肿(NPE)中组织因子(TF)及其抑制物(TFPI)的变化情况。方法：选择我院2007年6月~2010年5月收治的急性脑血管意外患者80例为研究组，其中，脑出血36例，脑梗死44例，选择同期健康体检者40例为对照组，分别采用酶联免疫吸附抗原法检测患者血浆TF、TFPI，并进行组间比较。结果：研究组患者血TF值均高于对照组，差异均有高度统计学意义(均P<0.01)；研究组中，脑出血患者血TFPI高于对照组，脑梗死患者血TFPI低于对照组，差异均有统计学意义(均P<0.05)。脑出血及脑梗死患者中并发神经源性肺水肿的患者，血TF、TFPI均高于未并发的神经源性肺水肿患者，差异有统计学意义(P<0.05)。结论：急性脑血管意外并发神经源性肺水肿的发生与凝血异常、炎症反应有关，组织因子及组织因子抑制物可能参与了肺损伤发生发展的过程。
[关键词] 急性脑血管意外；神经源性肺水肿；组织因子；组织因子途径抑制物
[中图分类号] R743 [文献标识码] A [文章编号] 1673-7210(2011)11(b)-039-02
Changes of tissue factor and tissue factor pathway inhibitor in acute cerebral vascular accident complicated neurogenic pulmonary edema
XU Zhaojun, BIE Huarong, TIAN Min, ZHENG Zhijuan, ZHANG Dongju
Department of Emergency, the First People's Hospital in Tianmen City, Hubei Province, Tianmen 431700, China
[Abstract] Objective: To investigate the changes of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in acute cerebral vascular accident complicated neurogenic pulmonary edema. Methods: 80 patients with acute cerebral vascular accident of which 36 cases of cerebral hemorrhage, 44 cases of cerebral infarction in our hospital from June 2007 to May 2010 were selected as the study group, 40 cases of healthy in the same period were chosen as the control group. TF, TFPI detected by ELISA technique and the results were compared. Results: TF level of study group was significantly higher than that of control group (all P<0.01); in the study group, TFPI of patients with cerebral hemorrhage was higher than that of control group, but TFPI of patients with cerebral infarction was lower than that of control group, the difference was statistically significant (all P<0.05); the levels of TF, TFPI of patients with neurogenic pulmonary edema were all higher than patients without that, the difference was statistically significant (P<0.05). Conclusion: The occurrence of neurogenic pulmonary edema in patients with acute cerebrovascular accident is relevant with coagulation abnormalities and inflammatory response; TF and TFPI may be involved in the development of lung injury process ......
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