收缩性心力衰竭患者血清N末端-脑钠肽前体水平检测分析(1)
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[摘要] 目的：探讨收缩性心力衰竭(SHF)患者血清N末端-脑钠肽前体(NT-proBNP)水平的变化及临床意义。方法：选择70例失代偿性SHF患者为SHF组，70例无器质性心脏病者为对照组。所有受试者均采用NYHA分级法分级诊断心功能，电化学发光双抗体夹心免疫法检测血清NT-proBNP水平，心脏彩色多普勒超声测定左心室射血分数(LVEF)。对比SHF组与对照组的血清NT-proBNP水平，分析SHF患者血清NT-proBNP水平与NYHA心功能级别和LVEF的关系。结果：SHF患者血清NT-proBNP水平为(3 695.2±1 425.7)ng/L，显著高于对照组[(65.5±18.9)ng/L](P<0.05)，并随NYHA心功能级别增高而升高。心功能Ⅱ、Ⅲ和Ⅳ级DHF患者血清NT-proBNP水平分别为(1 395.2±247.1)、(2 663.7±697.5)、(6 348.5±1 201.1)ng/L，组间比较，差异均有统计学意义(均P<0.05)。血清NT-proBNP水平与LVEF呈负相关，与LVEDd呈正相关。结论：血清NT-proBNP水平能较好地反映失代偿性SHF患者的心功能状态，有助于SHF的诊断和病情评估。
[关键词] 收缩性心力衰竭；N末端-脑钠肽前体
[中图分类号] R541 [文献标识码] B [文章编号] 1673-7210(2011)11(b)-082-02
Analysis of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with systolic heart failure
ZHANG Yanfang1, ZHANG Xingping2
1.Department of Cardiovasology, Qianjiang Central Hospital of Chongqing City, Chongqing 409000, China; 2.Department of Gerontology, the Third People's Hospital of Chongqing City, Chongqing 400014, China
[Abstract] Objective: To investigate the changes and clinical significance of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with systolic heart failure (SHF). Methods: 70 patients with decompensated SHF were selected in SHF group, and 70 patients without structural heart disease were selected in control group. All subjects were evaluated heart function by New York Heart Association (NYHA) class. Serum NT-proBNP level was assayed by electrochemiluminescence double antibody sandwich immunoassay. Left ventricular ejection fraction (LVEF) was detected by color Doppler ultrasound. The differences in NT-proBNP level between SHF and control group were compared, and the correlation among NT-proBNP levels and NYHA cardiac function class, LVEF was also analyzed. Results: NT-proBNP levels [(3 695.2±1 425 ......
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