高血压患者血清C-反应蛋白的表达(1)
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[摘要] 目的：探讨高血压患者血清C-反应蛋白(CRP)水平变化与预后的关系。方法：40例伴随不同程度动脉硬化的原发性高血压患者分别进行颈动脉粥样硬化检测及血清CRP测定，对测定结果进行统计学分析。结果：40例高血压患者中颈动脉粥样硬化者28例，无颈动脉粥样硬化者12例；同时颈动脉粥样硬化者的血清CRP平均水平明显高于无颈动脉粥样硬化者(t=6.232，P<0.05)。而在颈动脉粥样硬化者中，有颈动脉斑块的患者血清CRP显著高于颈动脉内膜(IMT)增厚患者(t=4.362，P<0.05)。治疗后，所有患者的CRP与治疗前比较均有明显改善，差异有统计学意义(P<0.05)。结论：高血压患者的CRP水平有助于动态评价病情变化和判断临床预后，可作为高血压患者预后不佳发生的重要预测指标，值得临床推广应用。
[关键词] 高血压；动脉硬化；C反应蛋白；预后
[中图分类号] R544.1 [文献标识码] B [文章编号] 1673-7210(2011)11(b)-173-02
Expression of C-reactive protein in hypertensive patients
CHEN Weiqin
Department of Internal Medicine, the Hu′nan Labor Health Prevention and Treatment of Occupational Diseases Hospital, Hu′nan Province, Changsha 410007, China
[Abstract] Objective: To discuss the relaiton of C-reactive protein (CRP) levels and prognosis in hypertensive patients. Methods: 40 patients with different degrees of atherosclerosis with essential hypertension were respectively detected carotid atherosclerosis and serum CRP. Results: Accorded the ultrasound results, 28 cases of carotid artery atherosclerosis and 12 cases without carotid artery atherosclerosis in the 40 cases of hypertension, the former's average level of serum CRP was significantly higher than the latter (t=6.232, P<0.05). In the carotid atherosclerosis, patients of carotid artery plaque with serum CRP was significantly higher than in patients with thickened IMT (t=4.362, P<0.05). After treatment, CRP of all patients were significantly improved, the difference was statistically significant(P<0.05). Conclusion: CRP levels in patients with high blood pressure can help dynamic evaluate of the disease changes and determine the clinical outcome, it can occur as an important prognostic predictor of poor, it is worthy of clinical application.
[Key words] Hypertension; Atherosclerosis; C-reactive protein; Prognosis
随着经济的发展和人们生活水平的提高以及生活方式的改变，高血压的发病率急剧升高，已成为主要的慢性病和公共卫生问题，同时其并发症多，影响因素也比较广泛，包括血脂代谢紊乱、肥胖、超重、高尿酸血症、高凝血低纤溶血症以及微量白蛋白尿等多种危险因素[1]。近年许多研究发现，血清C-反应蛋白(CRP)直接参与了高血压患者动脉粥样硬化的过程，导致预后不佳[2]。而在检查指标上，颈动脉内膜(IMT)增厚已经被公认为是动脉粥样硬化诊断的“金标准”[3]。为此本研究通过检测高血压患者血清CRP的水平变化与颈动脉超声IMT的变化，来探讨高血压患者血清CRP水平变化与预后的关系，现报道如下：
1资料与方法
1.1 一般资料
随机选择我院2010年1月~2011年2月收治的原发性高血压患者40例，均符合全国第四届脑血管病学术会议修订的诊断标准 ......
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