2型糖尿病颈动脉内膜中层病变及相关危险因素分析(1)
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[摘要] 目的：分析2型糖尿病患者颈动脉内膜中层厚度(CIMT)及其相关危险因素。方法：采用彩色多普勒超声仪测量115例2型糖尿病患者CIMT，并根据CIMT值将全部患者分为A组和B组，其中，A组患者62例，CIMT值≥1.0 mm，B组患者53例，CIMT值<1.0 mm，比较两组血糖、血压和血脂等代谢指标，并对与2型糖尿病CIMT增厚的相关危险因素进行评估。结果：A组患者的年龄、糖尿病病程、高血压病程、低密度脂蛋白胆固醇(LDL-C)、体重指数(BMI)明显高于B组，差异均有统计学意义(均P<0.05)，而两组三酰甘油、总胆固醇、高密度脂蛋白胆固醇、糖化血红蛋白、空腹血糖、餐后2小时血糖水平差异无统计学意义(P>0.05)。经Logistic回归分析显示，年龄、糖尿病病程、BMI、LDL-C水平是2型糖尿病患者CIMT增厚的独立相关危险因素(OR=1.093、1.088、1.038、1.732，均P<0.01)。结论：2型糖尿病患者CIMT增厚受多种因素影响，尤其与年龄、肥胖、糖尿病病程和LDL-C水平密切相关。
[关键词] 2型糖尿病；颈动脉内膜中层厚度；危险因素
[中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210(2011)12(a)-044-03
Study of carotid intima-media lesions and risk factors in patients with type 2 diabetes mellitus
ZENG Huafeng, ZHAO Xiaolin, YU Hongli, WEN Wen
Deparment of Endocrinology, Shayang People′s Hospital of Jingmen City, Hubei Province, Jingmen 448200, China
[Abstract] Objective: To investigate the carotid intima-media thickness (CIMT) and the related risk factors in patients with type 2 diabetes mellitus. Methods: CIMT of 115 cases of patients with type 2 diabetes were measured by B-mode ultrasonography. Then all patients were divided into two groups by the value of CIMT. 62 cases were in group A with CIMT≥1.0 mm and 53 cases were in group B with CIMT<1.0 mm. Levels of plasma glucose, blood pressure, blood lipids were measured in all patients, and the related risk factors were assessed by logistic regression analysis. Results: Age, course of diabetes, course of hypertensive, BMI and LDL-C were higher of group A than those of group B, the differences were significant (all P<0.05). Values of TG, TC, HDL-C, HBA1c, FBG, 2hPG were compared between the two groups, the differences were not significant (all P>0.05). By stepwise logistic regression analysis, age, course of diabetes, BMI and LDL-C were all independently correlated with CIMT(OR=1.093, 1.088, 1.038, 1.732, all P<0.01). Conclusion: CIMT bodiness is influenced by various kinds of factors, and which is highly associated with age, BMI, course of diabetes and LDL-C in patients with type 2 diabetes mellitus ......
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