血清胱抑素C和尿微量白蛋白在慢性肾小球肾炎早期肾功能损害评估中的意义(1)
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[摘要] 目的：探讨血清胱抑素C(Cys C)和24 h尿微量白蛋白(24 h U-mAlb)在慢性肾小球肾炎早期肾功能损害评估中的临床意义。方法：检测43例慢性肾小球肾炎早期肾功能损害患者(观察组)血清Cys C和24 h U-mAlb水平，并与43例健康体检者(正常对照组)进行对照分析。结果：慢性肾小球肾炎早期肾功能损害患者血清Cys C、24 h U-mAlb明显高于正常对照组(P<0.05)；慢性肾小球肾炎早期肾功能损害患者血清Cys C和24 h U-mAlb检出率比较，差异无统计学意义(P>0.05)。结论：血清 Cys C和24 h U-mAlb在慢性肾小球肾炎早期肾功能损害时升高均较为灵敏，二者可作为慢性肾小球肾炎早期肾功能损害评估的敏感指标。
[关键词] 慢性肾小球肾炎；血清胱抑素C；尿微量白蛋白
[中图分类号] R692.3 [文献标识码] B [文章编号] 1673-7210(2011)12(a)-095-02
The significance of the serum Cystatin C and uric microalbumin in evaluating the early renal impairment of the patients with chronic glomerulonephritis
ZHOU Biyan, LI Youyong, ZHONG Debin, QIN Zheng, WEN Yanfeng
Department of Clinical Laboratory, the First People′s Hospital of Nanning City, Guangxi Zhuang Autonomous Region, Nanning 530022, China
[Abstract] Objective: To study the clinical significance of the serum Cystatin C (Cys C) and uric microalbumin within 24 hours (24 h U-mAlb) in the early renal impairment of the patients with chronic glomerulonephritis. Methods: The serum Cys C and 24 h U-mAlb of 43 patients with chronic glomerulonephritis (observation group) were detected and compared with those of 43 healthy subjects (control group). Results: The serum Cys C and 24 h U-mAlb in the observation group were higher remarkably than those in the control group (P<0.05). There was no significant difference in detecting rate of the serum Cys C and 24 h U-mAlb in patients with chronic glomerulonephritis (P>0.05). Conclusion: The serum Cys C and 24 h U-mAlb are all sensitive in evaluating the renal impairment of the patients with chronic glomerulonephritis, and can become two sensitive indicators for evaluating the early renal impairment of the patients with chronic glomerulonephritis.
[Key words] Chronic glomerulonephritis; Serum cystatin C; Uric microalbumin
慢性肾小球肾炎(chronic glomerulonephritis)简称为慢性肾炎，系指由各种病原微生物感染通过免疫及非免疫机制等引起的双侧肾小球弥漫性或局灶性炎症性改变，以蛋白尿、血尿、高血压、水肿为主要临床表现，其病变缓慢、病情迁延，肾功能不同程度受损，最终可发展为慢性肾衰竭[1]。目前临床中用以评价肾功能的指标很多，如血中胱抑素C(Cystatin C，Cys C)、尿素氮、肌酐，尿液中的溶菌酶、淀粉酶、β-N-乙酰基-D-氨基葡萄糖苷酶、微量白蛋白、α1-微球蛋白、β2-微球蛋白(β2-MG)等[2] ......
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