长期饮酒对大鼠内外源性肺损伤时还原性谷胱甘肽、超氧化物歧化酶和丙二醛的影响(1)
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[摘要] 目的：探讨长期饮酒对内外源性肺损伤时氧化还原功能的影响。方法：采用长期饮酒后内、外源性肺损伤大鼠模型进行动脉血气、肺湿干比(W/D)和肺、肝组织还原性谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)检测。结果：长期饮酒后内、外源性肺损伤组大鼠肺、肝组织GSH水平较饮水损伤组明显下降，MDA水平显著升高，且外源性肺损伤组GSH、MDA改变较内源性肺损伤明显，差异均有统计学意义(P<0.05)。结论：长期饮酒导致肺脏抗氧化功能下降，加重了内、外源因素引起的肺损伤。
[关键词] 长期饮酒；急性肺损伤；谷胱甘肽
[中图分类号] R563 [文献标识码] A [文章编号] 1673-7210(2011)12(b)-012-03
The influence of chronic alcohol ingestion on glutathione, superoxide dismutase, malonaldehyde in rats with endogenous and external acute lung injury
LIU Yide1, LIU Zhi2
1.Department of Emergency, Shenyang Emergency Center, Liaoning Province, Shenyang 110006, China; 2.Department of Emergency, the First Affiliated Hospital of Chinese Medical University, Liaoning Province, Shenyang 110001, China
[Abstract] Objective: To explore the influence of chronic alcohol ingestion on redox function in rats with endogenous and external acute lung injury. Methods: The changs of PaO2, W/D value and the level of lutathione (GSH), superoxide dismutase (SOD), malonaldehyde (MDA) in lung and liver constitution of rats with acute lung injury caused by pulmonary and extrapulmonary disease were observed. Results: The levels of GSH in lung and liver tissue were statistically decreased, at the same time MDA level increased in alcohol-injury groups compared with water-injury groups, the differences were statistically significant (P<0.05). The changes of GSH, MDA level were more deteriorated of external acute lung injury than that of endogenous acute lung injury, the differences were statistically significant (P<0.05). Conclusion: Chronic alcohol ingestion can reduce the function of antioxidant defense of lungs and also aggravate the acute lung injury caused by intrinsic and extrinsic factors.
[Key words] Chronic alcohol ingestion; Acute lung injury; Glutathione
急性肺损伤(acute lung injury，ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome，ARDS)是指由心源性以外的各种肺内、外致病因素导致的急性进行性呼吸衰竭，临床表现为呼吸窘迫和顽固性低氧血症。引起ALI/ARDS的原因很多，可以分为内源性因素(严重肺炎等)和外源性因素(胰腺炎、休克等)[1]。国内外研究发现，肺内因素和肺外因素引起的ALI在发病机制、临床表现和治疗效果上有所不同。近年来，在临床治疗观察中人们发现，长期饮酒能明显增加危重患者ALI/ARDS发病率及病情严重程度[2] ......
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