慢性前列腺炎并不育患者血清抗精子抗体定量测定分析(1)
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[摘要] 目的：探讨慢性前列腺炎并不育患者血清抗精子抗体与不育的关系，为临床治疗提供依据。方法：采用酶联免疫吸附法(ELISA)检测80例慢性前列腺炎并不育患者(A组)血清抗精子抗体(AsAb)，同时选择正常生育的慢性前列腺炎患者50例(B组)作对照。结果：A组80例，检出AsAb阳性37例，阳性率46.3%，抗精子总抗体(T-Ig)(126.25±45.47)U/ml，B组AsAb阳性6例，阳性率12.0%，T-Ig(41.25±14.20)U/ml，两组阳性率及抗精子总抗体比较，差异均有统计学意义(均P<0.05)。结论：慢性前列腺炎并不育患者存在免疫性因素，ELISA方法敏感度高，操作简便，对临床合并前列腺炎的不育患者探求病因提供指导。
[关键词] 前列腺炎；男性不育症；抗精子抗体；酶联免疫吸附法
[中图分类号] R697.33 [文献标识码] A [文章编号] 1673-7210(2011)12(b)-049-02
Evaluation of antisperm antibodies detection in infertile men with chronic prostatitis
ZHENG Zheming1, YU Zhaocun1*,HUANG Zhihong2, XING Fashu1, CHEN Zaoqing1, HUANG Huasheng1, FANG Zhongjin1, YANG Changjun1
1.Department of Urology, Dongguan Houjie Affiliated Hospital, Guangdong Medical College, Guangdong Province, Dongguan 523945, China; 2. Department of Laboratory, Dongguan Houjie Affiliated Hospital, Guangdong Medical College, Guangdong Province, Dongguan 523945, China
[Abstract] Objective: To investigate the relationship between antisperm antibody (AsAb) and infertility men with prostatitis, and to provide some clue for clinic. Methods: Antisperm antibodies for infertile men with chronic prostatitis (n=80, group A) and fertile men with chronic prostatitis (n=50, group B) as control were respectively detected by the ELISA method. Results: The antisperm antibody was (126.25±45.47) U/ml in group A and (41.25±14.20) U/ml in group B, and the positive rate was 46.3% and 12.0% respectively, and there were significantly differences between two groups (all P<0.05). Conclusion: Infertile men with chronic prostatitis can be relate to sperm autoimmunity, ELISA method is a highly sensitive and easy experiment method, which can explore the cause of unknown infertility and provide the guidance of clinical treatment and prognosis.
[Key words] Chronic prostatitis; Male infertility; Anti-sperm antibody (AsAb); Enzyme linked immunosorbent assay (ELISA)
慢性前列腺炎是成年男性常见的生殖道感染性疾病，可通过影响精子的数量和质量而导致不育[1-2]，但其机制尚不完全明确。笔者采用酶联免疫吸附法(ELISA)通过定量测定慢性前列腺炎并不育患者80例血清抗精子抗体(AsAb)，探讨慢性前列腺炎血清抗精子抗体与不育的关系，现将结果报道如下：
1 资料与方法
1.1 一般资料
所有检测对象是2009年12月~2011年6月来我院不育症门诊就诊患者(经专科检查排除女方因素、器质性病变导致不孕不育)80例作为实验组(A组) ......
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