促红细胞生成素联合左旋肉碱对肾性贫血患者内皮素及左室重构临床研究(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 观察促红细胞生成素联合左旋肉碱对肾性贫血患者的疗效及对血清中内皮素(ET)的影响，以指导临床工作。 方法 收集我院尿毒症患者伴肾性贫血患者80例，将其随机分为观察组(40例)和对照组(40例)，对照组应用促红细胞生成素治疗，观察组应用促红细胞生成素联合左旋肉碱治疗，观察治疗后血红蛋白(Hb)、红细胞比容(HCT)、血浆内皮素(ET)、左心房内径(LAD)、左心室收缩末期内径(LVDs)、左心室舒张末期内径(LVDd)的变化。 结果 治疗前后的改变值观察组均明显高于对照组(P < 0.05)：Hb[(33.10±3.29)g/L vs (25.10±3.02)g/L]、HCT[(6.35±1.64)% vs (3.49±1.10)%]、ET[(107.10±19.62)pg/mL vs (52.32±10.54)pg/mL]；观察组治疗后均明显低于治疗前(P < 0.05)：LAD[(32.54±3.62)mm vs (35.43±3.62)mm]、LVDs[(31.29±2.65)mm vs (34.15±3.61)mm]及LVDd[(54.23±3.86)mm vs (59.75±4.32)mm]，对照组治疗前后比较，差异无统计学意义(P > 0.05)。 结论 促红细胞生成素联合左旋肉碱对肾性贫血患者的疗效明显，且能有效调节ET的水平，降低左室重构，在临床中可以积极应用。
[关键词] 促红细胞生成素；左旋肉碱；肾性贫血；内皮素
[中图分类号] R556 [文献标识码] A [文章编号] 1673-7210(2012)02(b)-0031-03
Clinical observation of Erythropoietin and L-carnitine for ET and left ventricular remodeling of patients with renal anemia
LIU Yuping LI Jinhuan ZHANG Xiujuan
The People′s Hospital of Juye County, Shandong Province, Juye 274900, China
[Abstract] Objective To observe the curative effect of Erythropoietin and L-carnitine in the treatment of patients with renal anemia, and the effect for ET, in order to direct clinical treatment. Methods 80 uremic patients with uremia and renal anemia in our hospital were randomly divided into control group (40 cases) and observation group (40 cases). The control group (40 cases) was treated by Erythropointin, the observation group (40 cases) was treated by Erythropoietin and L-carnitine. The change of Hb, HCT, ET, LAD, LVDs, LVDd were observed in the two groups. Results The change of Hb [(33.10±3.29)g/L vs (25.10±3.02)g/L], HCT [(6.35±1.64)% vs (3.49±1.10)%], ET [(107.10±19.62)pg/mL vs (52.32±10.54)pg/mL] were obviously better in the observation group than those in the control group (P < 0.05). There were significant differences before and after treatment on the LAD [(32.54±3.62)mm vs (35.43±3.62)mm], LVDs [(31.29±2.65)mm vs (34.15±3.61)mm], LVDd [(54.23±3.86)mm vs (59.75±4.32)mm] in the observation group, there was no significant difference in the control group (P > 0 ......
您现在查看是摘要介绍页，详见PDF附件(2849kb)。