β防御素-2和白细胞介素-1β在寻常型银屑病患者皮损中表达的研究(1)
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[摘要] 目的 探讨 β防御素-2 (HBD-2)和白细胞介素-1β (IL-1β)在寻常型银屑病皮损中的表达及其共同作用对银屑病皮损形成的影响。 方法 采用实时荧光定量逆转录聚合酶链反应(RT-PCR)法检测45例银屑病患者皮损区、非皮损区及15例正常人皮肤中HBD-2和IL-1β的表达情况，对其在皮损中的表达情况进行相关性分析，并将其与PASI评分进行相关性分析。 结果 与正常人皮肤组织和银屑病患者非皮损区相比，银屑病患者皮损区HBD-2和IL-1β的表达明显上调，非皮损区HBD-2和IL-1β的表达也高于正常人皮肤组织，差异均有统计学意义(均P < 0.05)。银屑病患者皮损中HBD-2和IL-1β的表达水平与PASI评分之间均存在正相关关系(P < 0.05)。 结论 HBD-2和IL-1β在寻常型银屑病皮损中的表达均升高，可能共同参与银屑病的发病过程。
[关键词] 寻常型银屑病；β防御素-2；白细胞介素-1β
[中图分类号] R758.63 [文献标识码] A [文章编号] 1673-7210(2012)02(c)-0021-03
Expression of β-defensin-2 and interleukin-1β in lesions of patients with psoriasis
ZHANG Pingping ZHEN Li
Department of Dermatology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
[Abstract] Objective To investigate the expressions of β-defensin-2 (HBD-2) and interleukin-1β (IL-1β) in the lesions skin tissues of psoriasis and the influence of its common action on forming of psoriasis lesions. Methods The lesions skin tissues, non-lesion tissues of 45 patients with psoriasis and the skin tissues of 15 cases of healthy people were selected, and the gene expression of HBD-2 and IL-1β were measured by real-time fluorescent quantitative reverse transcriptase polymerase chain reaction (RT-PCR). The correlation of the gene expression of HBD-2 and IL-1β was analyzed, and the relationship between the gene expression and PASI score was also analyzed. Results The gene expression of HBD-2 and IL-1β of the lesions skin tissues were significantly higher than that of the non-lesion tissues in patients with psoriasis and the normal skin in healthy people (all P < 0.05). The gene expression of HBD-2 and IL-1β of non-lesion tissues in patients with psoriasis were significantly higher than that of the normal skin in healthy people (P < 0.05). There was a positive correlation between the expression level of HBD-2 and IL-1β in the lesions skin tissues of patients with psoriasis and PASI score (P < 0.05). Conclusion The expression level of HBD-2, IL-1β in lesions skin tissues of psoriasis is rising, which may take part in the pathogenesis of psoriasis ......
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