[摘要] 目的 探讨异甘草酸镁对重型肝炎患者肝脏储备功能的影响。 方法 将105例重型肝炎患者随机分为治疗组(n = 56)和对照组(n = 49)，两组均采用综合内科治疗，治疗组加用异甘草酸镁200 mg静滴，1 d/次，疗程为4周。观察两组治疗前后肝功能和肝脏储备功能变化，并将所有病例分型、分期，比较各组病死率变化。 结果 经过4周治疗，治疗组肝功能好转程度与对照组比较，差异有统计学意义(P < 0.05)；肝脏储备功能检查：凝血酶原活动度(PTA)、胆碱酯酶(CHE)比较，两组差异有统计学意义(P < 0.05)，清蛋白两组比较差异无统计学意义(P > 0.05)。治疗组病死率为51.8%，对照组为75.5%，治疗组病死率明显低于对照组，差异有统计学意义(P < 0.05)。 结论 异甘草酸镁可显著改善重型肝炎肝功能，提高肝脏储备功能，降低病死率。

    [关键词] 重型肝炎；异甘草酸镁；肝脏储备功能；预后

    [中图分类号] R575[文献标识码] A[文章编号] 1673-7210(2012)03(c)-0057-03

    Effects of Magnesium Isoglycyrrhizinate on hepatic reserve function in severe hepatitis patients

    XU JianghaiZHANG GuobingWENG Junhua

    Department of Infectious Diseases, the Fifth People's Hospital of Anyang City, He'nan Province, Anyang 455000, China

    [Abstract] Objective To investigate the effects of Magnesium Isoglycyrrhizinate on hepatic reserve function in severehepatitis patients. Methods 105 cases of severe hepatitis patients were divided into treatment group (n = 56) and control group (n = 49), both groups were received comprehensive medical treatment ......