盐酸利托君治疗先兆早产85例临床效果观察(1)
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[摘要] 目的 探讨盐酸利托君抑制子宫宫缩、治疗先兆早产的临床效果和安全性。 方法 选择我院2007～2010年收治的先兆早产患者146例，按照入院日期，分为两组，单日为观察组70例，双日为对照组76例。观察组给予静脉滴注100 mg盐酸利托君+5%葡萄糖注射液500 mL，初始剂量为0.05 mg/min，根据宫缩情况每10分钟增加0.05 mg/min，最大剂量为0.35 mg/min，继而根据宫缩递减0.05 mg/min，宫缩抑制6～24 h，停止静注前30 min口服给予盐酸利托君，每2～6小时服用1～2片，根据宫缩情况逐渐减量，维持至34周。对照组给予硫酸镁首剂5.0 g静推，继而以1.5～2.0 g/h剂量静注，宫缩抑制后维持12～24 h，每日最大剂量为22 g。治疗结束后比较两组患者有效用药时间、延长妊娠时间及妊娠结局。 结果 观察组保胎成功率为97.1%，显著高于对照组65.8%(P < 0.01)，且平均有效时间和平均延长妊娠时间分别为(40.8±3.4)h和(21.5±4.7)d，显著高于对照组(P < 0.05)。观察组孕产妇接受治疗后产后出血发生率、围生儿死亡率、新生儿出生体重和Apgar评分均显著好于对照组(P < 0.05)。 结论 盐酸利托君治疗先兆早产效果显著，孕产妇和围生儿结局较为理想，虽不良反应发生率较高，但均可耐受，适用于先兆早产的延长妊娠治疗。
[关键词] 盐酸利托君；先兆早产；硫酸镁
[中图分类号] R714.21 [文献标识码] A [文章编号] 1673-7210(2012)04(a)-0091-02
Clinical study of Ritodrine Hydrochloride in the treatment of 85 cases with threatened premature labor
DAO Yulan OUYANG Yan SU Hong YANG Hongyue
Department of Obstetrics and Gynecology, Pu'er People's Hospital, Yunnan Province, Pu'er 665000, China
[Abstract] Objective To investigate the clinical effect of Ritodrine Hydrochloride for treating threatened premature labor. Methods 146 patients with threatened premature labor were selected and divided into two groups, 70 patients in observation group were given Ritodrine Hydrochloride 100 mg, which were dissolved into 5% Glucose Injection 500 mL for intravenous infusion with the initial dose of 0.05 mg/min, then dose were increased or decreased by 0.05 mg/min according to uterine contraction with the maximum of 0.35 mg/min. Ritodrine Hydrochloride were given by oral administration for 1-2 tablets per 2-6 h, then decreased according to uterine contraction and maintain for 34 weeks. 76 patients in control group were given magnesium sulfate with the initial dose of 5.0 mg for intravenous injection, then were given by dose of 1.5-2.0 g/h for intravenous infusion with the maximum of 22 g per day. Effective treatment time, extend time of pregnancy and pregnancy outcome were compared after treatment ......
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