氟桂利嗪与低分子肝素联合应用对频发性短暂脑缺血发作的疗效分析(1)
[摘要] 目的 分析联合应用氟桂利嗪与低分子肝素治疗频发性短暂脑缺血发作的疗效。 方法 选取146例频发性短暂脑缺血发作患者，按治疗方案不同分为两组：对照组，予以低分子肝素治疗，共77例；研究组，在低分子肝素基础上加用氟桂利嗪，共69例。治疗2周后，分别进行临床疗效及不良反应比较。 结果 与对照组比较，研究组总有效率、显效率明显较高(P < 0.05)，两组治疗后全血黏度(低切)、全血黏度(高切)、血浆黏度、纤维蛋白原含量较治疗前明显下降(P < 0.05)，但治疗后研究组较对照组明显改善(P < 0.05)。研究组的血细胞减少、皮疹、头痛、肝功能异常等不良反应较对照组差异无统计学意义(P > 0.05)。 结论 应用氟桂利嗪与低分子肝素治疗频发性短暂脑缺血发作疗效可靠，不良反应少。
[关键词] 氟桂利嗪；低分子肝素；短暂脑缺血发作；疗效；不良反应
[中图分类号] R742.3 [文献标识码] A [文章编号] 1673-7210(2012)07(b)-0060-03
Efficacy of Flunarizine and low molecular weight heparin for the frequency of recurrent transient ischemic attacks
WANG Dejun YU Lingling SUN Dongliang
The Second Department of Internal Medicine, Tanghai Affiliated Hospital of Hebei Union University, Hebei Province, Tanghai 063200, China
[Abstract] Objective To analyze the efficacy of the combination of Flunarizine and low molecular weight heparin for the frequency of recurrent transient ischemic attacks (TIA). Methods 146 cases of frequent TIA patients were randomly divided into 2 groups according to the treatment program. 77 patients of control group were given low molecular weight heparin, 69 patients of control group were treated with Flunarizine on the basis of low molecular weight heparin. The clinical efficacy and adverse reactions of two groups after treatment were compared. Results Compared with the control group, the utility and excellence rates of the study group were significantly higher (P < 0.05). Whole blood viscosity (low cut), whole blood viscosity (high shear), plasma viscosity, fibrinogen in the two groups after treatment were decreased significantly than before treatment (P < 0.05), but the study group were improved more significantly than the control group (P < 0.05). The adverse reactions of pancytopenia, rash, headache, abnormal liver function in tow groups were not significant different (P > 0.05). Conclusion The application of Flunarizine combined with low molecular weight heparin for the frequent TIA is reliable and has fewer adverse reactions.
[Key words] Flunarizine; Low molecular weight heparin; Transient ischemic attack; Efficacy; Adverse reactions
短暂性脑缺血发作(transient ischemic attack，TIA)是因各种因素导致的脑动脉短暂性或一过性脑组织供血障碍，造成相对应脑组织局灶性神经功能缺损或视网膜功能障碍，一般持续时间为数分钟至数小时，不超过24 h，症状反复发作，可完全恢复，且不遗留有神经功能缺损的临床表现[1]。目前认为频繁发作的短暂脑缺血发作是完全性脑卒中的重要危险因素之一，也是神经内科的急症，临床上应该予以足够的重视，必须及早治疗和迅速终止短暂脑缺血发作是有效防治脑血管病变的原则，以防发展为脑卒中[2]。本研究应用氟桂利嗪与低分子肝素治疗频发性短暂脑缺血发作疗效满意，现将结果报道如下：
1 资料与方法
1.1 一般资料
选择2007年1月～2011年8月我院住院的频发性短暂脑缺血发作患者146例作为研究对象，其中，男96例，女50例，平均年龄(68.6±7.7)岁，且均签订知情同意书。入选标准：①诊断符合全国第四次脑血管病学术会议(1995年)的标准[3]；②发病时限在24 h内；③发作次数大于每天2次或每周3次；④无严重的内科基础性疾病。排除标准：①经头颅CT或MRI证实无脑出血和与症状相符的病灶；②有胃肠道溃疡史者和活动性出血；③有血液系统疾病或出血倾向者；④有严重心、肺、肝、肾功能损害；⑤有治疗药物禁忌证。, 百拇医药(王德俊 于灵灵 孙东良)
[关键词] 氟桂利嗪；低分子肝素；短暂脑缺血发作；疗效；不良反应
[中图分类号] R742.3 [文献标识码] A [文章编号] 1673-7210(2012)07(b)-0060-03
Efficacy of Flunarizine and low molecular weight heparin for the frequency of recurrent transient ischemic attacks
WANG Dejun YU Lingling SUN Dongliang
The Second Department of Internal Medicine, Tanghai Affiliated Hospital of Hebei Union University, Hebei Province, Tanghai 063200, China
[Abstract] Objective To analyze the efficacy of the combination of Flunarizine and low molecular weight heparin for the frequency of recurrent transient ischemic attacks (TIA). Methods 146 cases of frequent TIA patients were randomly divided into 2 groups according to the treatment program. 77 patients of control group were given low molecular weight heparin, 69 patients of control group were treated with Flunarizine on the basis of low molecular weight heparin. The clinical efficacy and adverse reactions of two groups after treatment were compared. Results Compared with the control group, the utility and excellence rates of the study group were significantly higher (P < 0.05). Whole blood viscosity (low cut), whole blood viscosity (high shear), plasma viscosity, fibrinogen in the two groups after treatment were decreased significantly than before treatment (P < 0.05), but the study group were improved more significantly than the control group (P < 0.05). The adverse reactions of pancytopenia, rash, headache, abnormal liver function in tow groups were not significant different (P > 0.05). Conclusion The application of Flunarizine combined with low molecular weight heparin for the frequent TIA is reliable and has fewer adverse reactions.
[Key words] Flunarizine; Low molecular weight heparin; Transient ischemic attack; Efficacy; Adverse reactions
短暂性脑缺血发作(transient ischemic attack，TIA)是因各种因素导致的脑动脉短暂性或一过性脑组织供血障碍，造成相对应脑组织局灶性神经功能缺损或视网膜功能障碍，一般持续时间为数分钟至数小时，不超过24 h，症状反复发作，可完全恢复，且不遗留有神经功能缺损的临床表现[1]。目前认为频繁发作的短暂脑缺血发作是完全性脑卒中的重要危险因素之一，也是神经内科的急症，临床上应该予以足够的重视，必须及早治疗和迅速终止短暂脑缺血发作是有效防治脑血管病变的原则，以防发展为脑卒中[2]。本研究应用氟桂利嗪与低分子肝素治疗频发性短暂脑缺血发作疗效满意，现将结果报道如下：
1 资料与方法
1.1 一般资料
选择2007年1月～2011年8月我院住院的频发性短暂脑缺血发作患者146例作为研究对象，其中，男96例，女50例，平均年龄(68.6±7.7)岁，且均签订知情同意书。入选标准：①诊断符合全国第四次脑血管病学术会议(1995年)的标准[3]；②发病时限在24 h内；③发作次数大于每天2次或每周3次；④无严重的内科基础性疾病。排除标准：①经头颅CT或MRI证实无脑出血和与症状相符的病灶；②有胃肠道溃疡史者和活动性出血；③有血液系统疾病或出血倾向者；④有严重心、肺、肝、肾功能损害；⑤有治疗药物禁忌证。, 百拇医药(王德俊 于灵灵 孙东良)