c-Met、PTEN在甲状腺癌中的表达及其临床意义(1)
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[摘要] 目的 研究c-Met、PTEN 在甲状腺癌中的表达和临床价值。 方法 采用免疫组织化学SP法检测c-Met、PTEN在甲状腺癌、甲状腺腺瘤及正常甲状腺组织中的表达，并对其在不同病理类型、临床分期的甲状腺癌中的标记结果进行对照和相关性分析。 结果 c-Met、PTEN在72例甲状腺癌中的阳性率分别为63.9%和62.5%，与正常甲状腺、甲状腺腺瘤分别相比，差异有统计学意义(P < 0.05)。其在不同病理类型、临床分期、病理分级和区域淋巴结转移的甲状腺癌病例中的表达结果相比，差异有统计学意义(P < 0.05)，而与肿瘤大小、瘤体有无侵出包膜、患者性别及年龄无关(P > 0.05)。c-Met与PTEN的表达均呈负相关(r = -0.340，P < 0.01)。 结论 c-Met、PTEN在甲状腺癌的衍变过程中可能扮演重要角色，二者联合标记可能作为评估甲状腺癌恶性度及预后的有效参考，并可能为其靶向治疗提供思路。
[关键词] 甲状腺癌；PTEN；c-Met；免疫组织化学
[中图分类号] R736.1 [文献标识码] A [文章编号] 1673-7210(2012)08(a)-0007-04
Expression of c-Met, PTEN in thyroid carcinoma and its clinical significance
HAN Fei1,2 NAN Xinrong1
1.Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China; 2.Head and Neck Surgery, the Affiliated Shanxi Province Tumor Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China
[Abstract] Objective To explore the expression of c-Met and PTEN in thyroid carcinoma and its clinical value. Methods Expression of c-Met and PTEN in specimen of thyroid carcinoma (TC), thyroid adenomas and normal thyroid tissues was detected by SP method of immunohistochemistry (IHC). Then the marker results in those with different pathological category and clinical stages were compared, and correlation analysis was made. Results The positive rate of c-Met and PTEN in 72 TC specimen was 63.9% and 62.5%, compared with the normal thyroid tissues and thyroid adenomas respectively, there was a significant difference (P < 0.05). Also there were significant differences in sign results of different pathological types, the clinical and pathologic stages, classification and regional lymph node metastasis status (P < 0 ......
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