成纤维细胞生长因子受体2多态性与乳腺癌相关性研究(1)
 |
| 第1页 |
参见附件。
[摘要] 目的 研究成纤维细胞生长因子受体2(FGFR2)基因单核苷酸多态性(SNP)与乳腺癌相关性。 方法 对280例乳腺癌患者及280例健康女性进行ASA-PCR检测，分析其三个位点(rs2912778、rs2981582、rs2981578)SNP与乳腺癌风险关系。 结果 三个位点(rs2912778、rs2981582、rs2981578)基因型分布在乳腺癌组和对照组中差异具有统计学意义(P < 0.05)；与病理资料进一步联系分析，除rs2912778在淋巴结转移方面野生型与变异型差异具有高度统计学意义(P < 0.01)之外，其余三个位点野生型与变异型相比差异均无统计学意义(均P > 0.05)。 结论 FGFR2基因三个位点单核苷酸多态性可能与乳腺癌的发生有关。
[关键词] 成纤维细胞生长因子受体2；单核苷酸多态性；乳腺癌
[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-7210(2012)08(a)-0013-04
Relative research of FGFR2 Gene SNPs and breast neoplasm
XU Weihua1 WANG Shoubiao2▲
1.Department of Surgery, the People's Hospital of Penglai City, Shandong Province, Penglai 265600, China; 2.Department of Anatomy, School of Medicine in Qingdao University, Shandong Province, Qingdao 266000, China
[Abstract] Objective To investigate whether single nucleotide polymorphisms (SNP) of fibroblast growth receptor 2 (FGFR2) are associated with breast cancer risk. Methods In the present study of 280 breast cancer patients and 280 cancer-free controls, we tested three FGFR2 polymorphisms (rs2981582, rs2981578A/G and rs2912778) the method of ASA-PCR. Results Differences were found in the genotypes between the breast neoplasm group and the control group of all loci (P < 0.05). Among three loci, except rs2912778 (P < 0.01) in FGFR2 was related to lymph node metastasis, any difference between wild-type and variant-type in clinical pathological factors were not found (all P > 0.05). Conclusion The findings indicate that genetic variants in FGFR2 may contribute to breast cancer occurrence.
[Key words] Fibroblast growth factor receptor 2; Single nucleotide polymorphism; Breast neoplasm ......
您现在查看是摘要介绍页，详见PDF附件(3689kb)。