门冬胰岛素治疗初诊重度2型糖尿病的效果观察(1)
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[摘要] 目的 探讨门冬胰岛素治疗初诊重度2型糖尿病(T2DM)的疗效。 方法 将我院2009年3月～2012年3月80例初诊重度T2DM患者随机分为观察组(门冬胰岛素治疗，n = 40)和对照组(口服磺脲类治疗，n = 40)，观察治疗前和治疗6个月后两组患者的空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、空腹C肽及餐后2 h C肽，并加以分析。 结果 治疗6个月后，观察组的FBG、2 h PBG、HbA1c、空腹C肽及餐后2 h C肽变化明显优于对照组(P < 0.05)；两组患者的轻度低血糖发生率大体相当(P > 0.05)，重度低血糖发生率观察组明显低于对照组(P < 0.05)。 结论 门冬胰岛素是控制初诊重度T2DM血糖水平的有效方法，值得临床推广。
[关键词] 初诊；2型糖尿病；胰岛素；口服降糖药；疗效
[中图分类号] R587.2 [文献标识码] A [文章编号] 1673-7210(2012)08(c)-0076-03
Observation of curative effect on Insulin Aspartate in the treatment of newly diagnosed type 2 diabetes mellitus
DONG Yuxia1 XU Wenxiu1 CHANG Xiang1 WENG Jianping2
1.Department of Endocrinology, Wuwei People's Hospital, Gansu Province, Wuwei 733000, China; 2.Department of Endocrinology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangdong Province, Guangzhou 510630, China
[Abstract] Objective To investigate the efficacy of Insulin Aspartate in the treatment of newly diagnosed severe type 2 diabetes Mellitus (T2DM). Methods 80 cases of newly diagnosed severe T2DM treated in our hospital from March 2009 to March 2012 were randomLy assigned to observation group (Insulin Aspartate treatment, n = 40) and control group (oral sulfonylurea therapy, n = 40). FBG, 2 h PBG, HbA1c and fasting and 2 h postprandial C-peptide of the two groups before treatment and 6 months after treatment were observed and analyzed. Results After 6 months of treatment, FBG, 2 h PBG, HbA1c and fasting and 2 h postprandial C-peptide in the observation group were significantly better than in the control group (P < 0.05); mild hypoglycemia incidence was roughly the same in the two groups (P > 0 ......
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