血清白介素6与胱抑素C联合检测对糖尿病肾脏疾病早期的诊断价值(1)
[摘要] 目的 分析血清白介素6(IL-6)与胱抑素C(CysC)联合检测对糖尿病肾脏疾病(DKD)早期的诊断价值。方法 选取常德职业技术学院附属第一医院肾内科2012年6月～2013年6月收治的110例糖尿病(DM)患者，其中65例患者尿白蛋白排泄率(UAER)<20 μg/min设置为无早期肾损伤组，即DM组，其余45例糖尿病患者UAER 20～200 μg/min设置为糖尿病肾脏疾病组，即DKD组，统计分析两组患者CysC、IL-6水平。 结果 DKD组患者CysC、IL-6、CRP水平显著高于DM组(P < 0.05)。DKD组患者CysC、IL-6单项检测阳性率为60.0%、75.6%，双项阳性率为84.4%，而DM组阳性率分别为27.7%、36.9%、44.6%，两者差异有统计学意义(P < 0.05)，两组患者CysC、IL-6单项检测阳性率显著低于CysC、IL-6双项检测阳性率(P < 0.05)。 结论 IL-6与CysC联合检测可有效提高糖尿病肾脏疾病检测阳性率，是早期糖尿病肾脏疾病确诊的重要方法之一。
[关键词] 血清白介素6；胱抑素C；糖尿病肾脏疾病
[中图分类号] R587.2[文献标识码] A[文章编号] 1673-7210(2014)05(a)-0078-03
Serum interleukin-6 and cystitis C combined detection in diagnosis of early diabetic kidney disease
LIU Guoyong1 HE Liyu2 SHI Yan1 YI Fayun1 XIAO Guoqiu1 YANG Qing1 SHE Jian1 XU Haiqin1 LONG Qing1
1.Department of Internal Medicine, the First Affiliated Hospital of Career Technical College in Changde City, Hu′nan Province, Changde 415000, China; 2.Research Institute of Nephrology, Xiangya Second Hospital of Central South University in Changsha, Hu′nan Province, Changsha 410016, China
[Abstract] Objective To analyze the early diagnostic value of the serum interleukin 6 (IL 6) and joint detection (inhibition C (CysC) on diabetic kidney disease (DKD). Methods 110 cases of treated diabetes in Department of Internal Medicine of the First Affiliated Hospital of Career Technical College in Changde City were selected from June 2012 to June 2013, including 65 cases of urinary albumin excretion rate (UAER) < 20 μg/min which was setted to no early renal injury group (DM group), and the remaining 45 cases diabetes UAER 20 - 200 μg/min which was setted for diabetic kidney disease group (DKD group), two groups of patients with the level of IL-6 and Cys C were statistically analyzed. Results DKD patients of CysC, IL-6, CRP levels were significantly higher than those in DM group (P < 0.05). DKD patients for single test positive rate of CysC, IL-6 was 60.0%, 75.6%, double entry positive rate were 84.4%, while the positive rate of DM group was 27.7%, 36.9%, 44.6%, respectively, the difference was significant (P < 0.05 ), single positive rate of CysC, IL-6 in two groups were significantly lower than those of CysC, IL-6 double entry positive rate (P < 0.05). Conclusion IL-6 and CysC joint detection can effectively improve the detection rate of diabetic kidney disease, and it is one of the important methods of diagnosis early diabetic kidney disease.
[Key words] Serum interleukin 6; Cystatin C; Diabetic kidney disease
糖尿病肾脏疾病是糖尿病的重要并发症之一，该疾病发病机制较为复杂，多表现为患者免疫功能病变。糖尿病肾脏疾病病发后患者肾脏功能将严重损伤，进而导致其他并发症，严重威胁患者生活质量[1]。目前，糖尿病肾脏疾病的防治重点是发病早期的及时治疗，因此，及时准确的确诊工作成为糖尿病肾脏疾病防治的重要工作重心之一。血清白介素6(IL-6)与胱抑素C(CysC)是临床糖尿病肾脏疾病确诊工作的主要标志物[2]，因此，笔者选取湖南省常德职业技术学院附属第一医院(以下简称“我院”)2012年6月～2013年6月收治的110例糖尿病(DM)患者进行了相关研究，现报道如下：
1 资料与方法
1.1 一般资料
选取我院肾内科2012年6月～2013年6月收治的110例DM患者，其中65例患者尿白蛋白排泄率(UAER)<20 μg/min定为无早期肾损伤组，即DM组，其余45例糖尿病患者UAER 20～200 μg/min定为糖尿病肾脏疾病组，即糖尿病肾脏疾病(DKD)组。DM组患者男女比例为38∶27，年龄为45～78岁，平均(51.3±1.8)岁；DKD组患者男女比例为24∶21，年龄为43～76岁，平均(49.6±1.2)岁。两组患者年龄、性别等资料差异无统计学意义(P > 0.05)，具有可比性。本研究研究获得我院医学伦理委员会批准，所有入选者知情同意参加研究。, http://www.100md.com(刘国勇 贺理宇 石艳 易法云 肖国球 杨青 佘建 徐海琴 龙庆)
[关键词] 血清白介素6；胱抑素C；糖尿病肾脏疾病
[中图分类号] R587.2[文献标识码] A[文章编号] 1673-7210(2014)05(a)-0078-03
Serum interleukin-6 and cystitis C combined detection in diagnosis of early diabetic kidney disease
LIU Guoyong1 HE Liyu2 SHI Yan1 YI Fayun1 XIAO Guoqiu1 YANG Qing1 SHE Jian1 XU Haiqin1 LONG Qing1
1.Department of Internal Medicine, the First Affiliated Hospital of Career Technical College in Changde City, Hu′nan Province, Changde 415000, China; 2.Research Institute of Nephrology, Xiangya Second Hospital of Central South University in Changsha, Hu′nan Province, Changsha 410016, China
[Abstract] Objective To analyze the early diagnostic value of the serum interleukin 6 (IL 6) and joint detection (inhibition C (CysC) on diabetic kidney disease (DKD). Methods 110 cases of treated diabetes in Department of Internal Medicine of the First Affiliated Hospital of Career Technical College in Changde City were selected from June 2012 to June 2013, including 65 cases of urinary albumin excretion rate (UAER) < 20 μg/min which was setted to no early renal injury group (DM group), and the remaining 45 cases diabetes UAER 20 - 200 μg/min which was setted for diabetic kidney disease group (DKD group), two groups of patients with the level of IL-6 and Cys C were statistically analyzed. Results DKD patients of CysC, IL-6, CRP levels were significantly higher than those in DM group (P < 0.05). DKD patients for single test positive rate of CysC, IL-6 was 60.0%, 75.6%, double entry positive rate were 84.4%, while the positive rate of DM group was 27.7%, 36.9%, 44.6%, respectively, the difference was significant (P < 0.05 ), single positive rate of CysC, IL-6 in two groups were significantly lower than those of CysC, IL-6 double entry positive rate (P < 0.05). Conclusion IL-6 and CysC joint detection can effectively improve the detection rate of diabetic kidney disease, and it is one of the important methods of diagnosis early diabetic kidney disease.
[Key words] Serum interleukin 6; Cystatin C; Diabetic kidney disease
糖尿病肾脏疾病是糖尿病的重要并发症之一，该疾病发病机制较为复杂，多表现为患者免疫功能病变。糖尿病肾脏疾病病发后患者肾脏功能将严重损伤，进而导致其他并发症，严重威胁患者生活质量[1]。目前，糖尿病肾脏疾病的防治重点是发病早期的及时治疗，因此，及时准确的确诊工作成为糖尿病肾脏疾病防治的重要工作重心之一。血清白介素6(IL-6)与胱抑素C(CysC)是临床糖尿病肾脏疾病确诊工作的主要标志物[2]，因此，笔者选取湖南省常德职业技术学院附属第一医院(以下简称“我院”)2012年6月～2013年6月收治的110例糖尿病(DM)患者进行了相关研究，现报道如下：
1 资料与方法
1.1 一般资料
选取我院肾内科2012年6月～2013年6月收治的110例DM患者，其中65例患者尿白蛋白排泄率(UAER)<20 μg/min定为无早期肾损伤组，即DM组，其余45例糖尿病患者UAER 20～200 μg/min定为糖尿病肾脏疾病组，即糖尿病肾脏疾病(DKD)组。DM组患者男女比例为38∶27，年龄为45～78岁，平均(51.3±1.8)岁；DKD组患者男女比例为24∶21，年龄为43～76岁，平均(49.6±1.2)岁。两组患者年龄、性别等资料差异无统计学意义(P > 0.05)，具有可比性。本研究研究获得我院医学伦理委员会批准，所有入选者知情同意参加研究。, http://www.100md.com(刘国勇 贺理宇 石艳 易法云 肖国球 杨青 佘建 徐海琴 龙庆)