RhoA/ROCK途径在高血压发病机制中的研究进展(1)
[摘要] RhoA/Rho激酶(RhoA/ROCK)途径在许多病理状态中起重要作用。RhoA蛋白参与了血管平滑肌张力的调节并激活许多下游激酶。ROCK是RhoA的下游激酶之一，ROCK在局部血流和血压中发挥各种重要功能。ROCK激活可维持肌球蛋白轻链激酶的活性导致肌动蛋白/肌球蛋白的相互作用和平滑肌细胞的收缩，这一作用独立于游离胞质钙的水平。本文对RhoA/ROCK与高血压之间的关系作一综述，更好地理解这一通路在高血压中的作用机制。
[关键词] RhoA/RO激酶；高血压；活性氧；血管紧张素 Ⅱ
[中图分类号] R544.1 [文献标识码] A [文章编号] 1673-7210(2015)05(c)-0028-05
[Abstract] RhoA/ROCK pathway plays an important role in many pathological diseases. RhoA participates in the regulation of smooth muscle tone and activates many downstream kinases. ROCK is one of the downstream kinases of RhoA. ROCK is necessary for diverse functions such as local blood flow ......
您现在查看是摘要页，全文长 5007 字符。
[关键词] RhoA/RO激酶；高血压；活性氧；血管紧张素 Ⅱ
[中图分类号] R544.1 [文献标识码] A [文章编号] 1673-7210(2015)05(c)-0028-05
[Abstract] RhoA/ROCK pathway plays an important role in many pathological diseases. RhoA participates in the regulation of smooth muscle tone and activates many downstream kinases. ROCK is one of the downstream kinases of RhoA. ROCK is necessary for diverse functions such as local blood flow ......
您现在查看是摘要页，全文长 5007 字符。