单唾液酸四己糖神经节苷脂钠联合中频电疗治疗小儿中枢神经协调障碍的临床效果(1)
[摘要] 目的 观察单唾液酸四己糖神经节苷脂钠联合中频电疗治疗小儿中枢神经协调障碍的临床效果，分析其临床应用价值。 方法 选取2014年1月～2015年1月在内江市第一人民医院治疗的中枢神经协调障碍患儿100例作为研究对象并进行回顾性分析，根据治疗方法不同分为实验组和对照组，每组各50例。对照组患儿给予传统的康复治疗，实验组患儿在传统康复治疗的基础上给予单唾液酸四己糖神经节苷脂钠联合中频电疗治疗。观察两组患者的临床疗效、盖泽尔发育量表(GESELL)各项指标评分、意识障碍、肌张力异常以及原始反射异常情况。 结果 两组患儿治疗前各项GESELL评分比较，差异无统计学意义(P > 0.05)；两组患儿治疗后各项GESELL评分与治疗前比较，差异有统计学意义(P < 0.05)；治疗后实验组及对照组患儿的大运动评分[(38.78±10.26)、(31.06±9.74)分]、精细运动评分[(43.26±8.98)、(38.05±7.62)分]以及适应性评分[(59.35±8.26)、(52.17±8.86)分]比较，差异均有统计学意义(P < 0.05)；语言评分[(49.26±10.18)、(48.69±9.97)分]和个人社交评分[(42.25±6.34)、(41.89±6.76)分]比较，差异无统计学意义(P > 0.05)。治疗后，实验组患儿显效23例，有效26例，无效1例，总有效率为98.0%；对照组显效15例，有效24例，无效11例，总有效率为78.0%，两组总有效率比较，差异均有统计学意义(P < 0.05)。治疗后，两组患儿在意识障碍、肌张力异常、原始反射异常的持续时间比较，差异有统计学意义(P < 0.05)。 结论 单唾液酸四己糖神经节苷脂钠联合中频电疗治疗小儿中枢神经协调障碍效果显著，具有一定的临床应用价值。
[关键词] 单唾液酸四己糖神经节苷脂钠；中频电疗；中枢神经协调障碍；临床疗效
[中图分类号] R742.3 [文献标识码] A [文章编号] 1673-7210(2015)07(b)-0044-04
[Abstract] Objective To observe the clinical curative effect of single sialic acid four hexose ganglioside sodium combined with intermediate frequency electrotherapy on treatment of children's central nervous coordination disorder， and analyze its clinical application value. Methods From 2014 January to January 2015， in the First People's Hospital of Neijiang City， 100 childern with central nervous coordination disorder were selected as research object and retrospectively analyzed， according to the different treatment method， they were divided into experiment group and control group， with 50 cases in each group. children in control group were given conventional rehabilitation treatment， and experimen group were given single sialic acid four hexose ganglioside sodium combined with intermediate frequency electrotherapy treatment based on traditional rehabilitation therapy. The clinical effects， the indicators score of GESELL， disturbance of consciousness， abnormal muscle tone， the original reflection anomaly in two groups were observed. Results There was no statistically significant difference between GESELL score of two groups before treatment (P > 0.05)； after treatment， big movement scores [(38.78±10.26)， (31.06±9.74) scores]， fine motor scores [(43.26±8.98)， (38.05±7.62) scores] and adaptability scores [(59.35±8.26)， (52.17±8.86) scores] of the experimen group and control group were compared， the differences were statistically significant (P < 0.05)； language scores [(49.26±10.18)， (48.69±9.97) scores] and personal social scores [(42.25±6.34)， (41.89±6.76) scores] of two groups were compared， the differences were not statistically significant (P > 0.05). After the treatment， in experimen group， excellent were 23 cases， effective were 26 cases， invalid was 1 case， the clinical total effective rate was 98.0%； in control group， excellent were 15 cases， effective 24 cases， invalid were 11 cases， the clinical total effective rate was 78.0%， the clinical total effective rate in two groups were compared， the difference was statistically significant (P < 0.05). After the treatment， the duration of disturbance of consciousness， muscle tension， primitive reflex abnormalities in two groups were compared， the differences were statistically significant (P < 0.05). Conclusion Single sialic acid four hexose ganglioside sodium combined with intermediate frequency electrotherapy has obvious curative effect on treating pediatric central nervous coordination disorder， this method has certain application value in clinic. (钟守萍)
[关键词] 单唾液酸四己糖神经节苷脂钠；中频电疗；中枢神经协调障碍；临床疗效
[中图分类号] R742.3 [文献标识码] A [文章编号] 1673-7210(2015)07(b)-0044-04
[Abstract] Objective To observe the clinical curative effect of single sialic acid four hexose ganglioside sodium combined with intermediate frequency electrotherapy on treatment of children's central nervous coordination disorder， and analyze its clinical application value. Methods From 2014 January to January 2015， in the First People's Hospital of Neijiang City， 100 childern with central nervous coordination disorder were selected as research object and retrospectively analyzed， according to the different treatment method， they were divided into experiment group and control group， with 50 cases in each group. children in control group were given conventional rehabilitation treatment， and experimen group were given single sialic acid four hexose ganglioside sodium combined with intermediate frequency electrotherapy treatment based on traditional rehabilitation therapy. The clinical effects， the indicators score of GESELL， disturbance of consciousness， abnormal muscle tone， the original reflection anomaly in two groups were observed. Results There was no statistically significant difference between GESELL score of two groups before treatment (P > 0.05)； after treatment， big movement scores [(38.78±10.26)， (31.06±9.74) scores]， fine motor scores [(43.26±8.98)， (38.05±7.62) scores] and adaptability scores [(59.35±8.26)， (52.17±8.86) scores] of the experimen group and control group were compared， the differences were statistically significant (P < 0.05)； language scores [(49.26±10.18)， (48.69±9.97) scores] and personal social scores [(42.25±6.34)， (41.89±6.76) scores] of two groups were compared， the differences were not statistically significant (P > 0.05). After the treatment， in experimen group， excellent were 23 cases， effective were 26 cases， invalid was 1 case， the clinical total effective rate was 98.0%； in control group， excellent were 15 cases， effective 24 cases， invalid were 11 cases， the clinical total effective rate was 78.0%， the clinical total effective rate in two groups were compared， the difference was statistically significant (P < 0.05). After the treatment， the duration of disturbance of consciousness， muscle tension， primitive reflex abnormalities in two groups were compared， the differences were statistically significant (P < 0.05). Conclusion Single sialic acid four hexose ganglioside sodium combined with intermediate frequency electrotherapy has obvious curative effect on treating pediatric central nervous coordination disorder， this method has certain application value in clinic. (钟守萍)