黄葵胶囊联合氯沙坦治疗慢性肾小球肾炎的效果(1)
[摘要] 目的 探讨黄葵胶囊联合氯沙坦治疗慢性肾小球肾炎的效果。 方法 回顾性分析陕西省榆林市第二医院2012年2月～2015年4月收治的慢性肾小球肾炎患者180例的临床资料，依据治疗方式的不同将患者分为两组，对照组80例采取氯沙坦治疗，观察组100例采取黄葵胶囊联合氯沙坦治疗。观察两组患者治疗前后尿素氮、肌酐、24 h尿蛋白定量以及临床疗效情况。 结果 对照组和观察组治疗前尿素氮[(5.8±0.5)、(5.9±0.6)mmol/L]、肌酐[(235.8±10.4)、(237.0±10.3)μmol/L]、24 h尿蛋白定量[(1.8±0.7)、(1.7±0.6)g]比较差异无统计学意义(t = 1.20、0.77、1.03，均P > 0.05)。观察组治疗后尿素氮[(6.2±0.3)mmol/L]、肌酐[(227.8±3.6)μmol/L]、24 h尿蛋白定量[(0.8±0.2)g]优于对照组[(6.0±0.4)mmol/L、(231.2±6.6)μmol/L、(1.2±0.4)g]，差异均有统计学意义(t = 3.83、4.40、8.73，均P < 0.05)。两组治疗后尿素氮、肌酐、24 h尿蛋白定量均显著优于治疗前(均P < 0.05)。观察组总有效率(100%)明显高于对照组(85%)，差异有统计学意义(χ2=16.22，P < 0.05)。 结论 黄葵胶囊联合氯沙坦治疗慢性肾小球肾炎患者可以明显降低蛋白尿，保护肾脏功能，临床疗效明显，值得推广应用。
, 百拇医药
[关键词] 黄葵胶囊；氯沙坦；慢性肾小球肾炎；效果
[中图分类号] R692.3 [文献标识码] A [文章编号] 1673-7210(2015)08(c)-0150-04
[Abstract] Objective To explore the effect of Huangkui Capsule combined with Losartan in the treatment of chronic glomerulonephritis. Methods The clinical data of 180 cases of patients with chronic glomerulonephritis in the Second Hospital of Yulin City from February 2012 to April 2015 was analyzed retrospectively. The patients were divided into two groups according to different treatment methods， 80 cases of control group were treated by Losartan， 100 cases of observation group were treated by Huangkui Capsule combined with Losartan. The blood urea nitrogen， creatinine， 24 h urine protein quantitation and clinical effect before and after treatment of the two groups were observed. Results The levels of blood urea nitrogen [(5.8±0.5)， (5.9±0.6) mmol/L]， creatinine [(235.8±10.4)， (237.0±10.3) μmol/L]， 24 h urine protein quantitation [(1.8±0.7)， (1.7±0.6) g] before treatment of control group and observation group had no statistically significant differences (t = 1.20， 0.77， 1.03， all P > 0.05). The levels of blood urea nitrogen [(6.2±0.3) mmol/L]， creatinine [(227.8±3.6) μmol/L]， 24 h urine protein quantitation [(0.8±0.2) g] after treatment in observation group were all better than those of control group [(6.0±0.4) mmol/L， (231.2±6.6) μmol/L， (1.2±0.4) g]， the differences were all statistically significant (t = 3.83， 4.40， 8.73， all P < 0.05). The levels of blood urea nitrogen， creatinine， 24 h urine protein quantitation after treatment in the two groups were all better than those before treatment (all P < 0.05). The total effective rate of observation group (100%) was higher than that of control group (85%)， the difference was statistically significant (χ2=16.22， P < 0.05). Conclusion Huangkui Capsule combined with Losartan in the treatment of chronic glomerulonephritis can decrease proteinuria obviously， protect renal function， which has a significant clinical effect and is worthy of promotion and application., 百拇医药(王祝娟)
, 百拇医药
[关键词] 黄葵胶囊；氯沙坦；慢性肾小球肾炎；效果
[中图分类号] R692.3 [文献标识码] A [文章编号] 1673-7210(2015)08(c)-0150-04
[Abstract] Objective To explore the effect of Huangkui Capsule combined with Losartan in the treatment of chronic glomerulonephritis. Methods The clinical data of 180 cases of patients with chronic glomerulonephritis in the Second Hospital of Yulin City from February 2012 to April 2015 was analyzed retrospectively. The patients were divided into two groups according to different treatment methods， 80 cases of control group were treated by Losartan， 100 cases of observation group were treated by Huangkui Capsule combined with Losartan. The blood urea nitrogen， creatinine， 24 h urine protein quantitation and clinical effect before and after treatment of the two groups were observed. Results The levels of blood urea nitrogen [(5.8±0.5)， (5.9±0.6) mmol/L]， creatinine [(235.8±10.4)， (237.0±10.3) μmol/L]， 24 h urine protein quantitation [(1.8±0.7)， (1.7±0.6) g] before treatment of control group and observation group had no statistically significant differences (t = 1.20， 0.77， 1.03， all P > 0.05). The levels of blood urea nitrogen [(6.2±0.3) mmol/L]， creatinine [(227.8±3.6) μmol/L]， 24 h urine protein quantitation [(0.8±0.2) g] after treatment in observation group were all better than those of control group [(6.0±0.4) mmol/L， (231.2±6.6) μmol/L， (1.2±0.4) g]， the differences were all statistically significant (t = 3.83， 4.40， 8.73， all P < 0.05). The levels of blood urea nitrogen， creatinine， 24 h urine protein quantitation after treatment in the two groups were all better than those before treatment (all P < 0.05). The total effective rate of observation group (100%) was higher than that of control group (85%)， the difference was statistically significant (χ2=16.22， P < 0.05). Conclusion Huangkui Capsule combined with Losartan in the treatment of chronic glomerulonephritis can decrease proteinuria obviously， protect renal function， which has a significant clinical effect and is worthy of promotion and application., 百拇医药(王祝娟)