经颅直流电刺激对帕金森病非运动症状的疗效(1)
[摘要] 目的 探讨经颅直流电刺激对帕金森病非运动症状的疗效。 方法 选取2014年6月～2015年6月在山东东营胜利石油管理局胜利医院就诊的60例帕金森病非运动症状患者作为研究对象，按照随机数字表法分为治疗组和对照组，每组各30例。两组均给予药物和康复锻炼，治疗组在常规治疗的基础上给予经颅直流电刺激。治疗后采取调查问卷的方法比较两组患者蒙特利尔认知评估量表(MoCA)、匹兹堡睡眠质量指数(PSQI)、生命质量(QOL)得分状况。 结果 对照组患者治疗前MoCA评分为(15.2±2.7)分，治疗10 d得分为(21.2±2.0)分，治疗20 d得分为(30.0±1.3)分，治疗组患者分别为(16.7±3.6)、(24.1±2.9)、(36.0±2.1)分，两组得分治疗前差异无统计学意义(P > 0.05)，治疗后差异均有统计学意义(P < 0.05)。对照组患者治疗前PSQI评分为(12.5±2.0)分，治疗10 d得分为(16.3±1.0)分，治疗20 d得分为(17.4±1.0)分；治疗组患者分别为(13.0±1.5)、(19.0±2.0)、(26.2±1.5)分，两组得分治疗前差异无统计学意义(P > 0.05)，治疗后差异均有统计学意义(P < 0.05)。对照组患者治疗前QOL评分为(10.5±2.2)分，治疗10 d得分为(17.5±2.4)分，治疗20 d得分为(26.4±1.0)分；治疗组患者分别为(11.9±1.8)、(21.1±2.0)、(34.8±1.5)分，两组得分治疗前差异无统计学意义(P > 0.05)，治疗后差异均有统计学意义(P < 0.05)。 结论 经颅直流电刺激能改善帕金森病患者的非运动症状，进而提高患者的生活质量。
[关键词] 经颅直流电刺激；帕金森病；非运动症状
[中图分类号] R742.5 [文献标识码] A [文章编号] 1673-7210(2016)02(b)-0075-04
Effect of transcranial direct current stimulation for non-motor symptoms of Parkinson's disease
WAGN Guangjun1 ZHAO Zhenhua1 WU Dongchuan1 LI Jian1 ZHENG Yi1 WU Xiaoxia2 ZHAO Xuan1 TIAN Bin1
1.Department of Medical Neurology， Shengli Hospital of Shengli Petroleum Administration Bureau of Sinopec Group， Shandong Province， Dongying 257055， China； 2.Department of Cardiovascular， Shengli Hospital of Shengli Petroleum Administration Bureau of Sinopec Group， Shandong Province， Dongying 257055， China
[Abstract] Objective To investigate effect of transcranial direct current stimulation for non-motor symptoms of Parkinson's disease. Methods From June 2014 to June 2015， in Shandong Dongying Shengli Hospital of Shengli Petroleum Administration Bureau， 60 patients with non-motor symptoms of Parkinson's disease were selected as research subjects， according to random number table， patients were divided into treatment group and control group， with 30 cases in each group. Two groups were given drugs and rehabilitation exercises， the treatment group were given transcranial direct current stimulation on the basis of conventional therapy. After the treatment， Montreal cognitive assessment (MoCA)， Pittsburgh sleep quality index (PSQI)， quality of life (QOL) were as questionnaire， and the scores of two groups were compared. Results MoCA score of patients in control group before treatment was (15.2±2.7) scores， after treatment 10 d that was (21.2±2.0) scores， after treatment 20 d that was (30.0±1.3) scores， these of in treatment group were (16.7±3.6)， (24.1±2.9)， (36.0±2.1) scores， the scores of two groups before treatment were compared， the difference was not statistically significant (P > 0.05)， those after the treatment were compared， the differences were statistically significant (P < 0.05). PSQI score of patients in control group before treatment was (12.5±2.0) scores， after treatment 10 d that was (16.3±1.0) scores， after treatment 20 d that was (17.4±1.0) scores， these of in treatment group were (13.0±1.5)， (19.0±2.0)， (26.2±1.5) scores， the scores of two groups before treatment were compared， the difference was not statistically significant (P > 0.05)， those after the treatment were compared， the differences were statistically significant (P < 0.05). QOL score of patients in control group before treatment was (10.5±2.2) scores， after treatment 10 d that was (17.5±2.4) scores， after treatment 20 d that was (26.4±1.0) scores， these of in treatment group were (11.9±1.8)， (21.1±2.0)， (34.8±1.5) scores， the scores of two groups before treatment were compared， the difference was not statistically significant (P > 0.05)， those after the treatment were compared， the differences were statistically significant (P < 0.05). Conclusion Transcranial direct current stimulation can improve the non-motor symptoms and quality of life of patients with Parkinson's disease., 百拇医药(王广君 赵振华 吴东川 等)
[关键词] 经颅直流电刺激；帕金森病；非运动症状
[中图分类号] R742.5 [文献标识码] A [文章编号] 1673-7210(2016)02(b)-0075-04
Effect of transcranial direct current stimulation for non-motor symptoms of Parkinson's disease
WAGN Guangjun1 ZHAO Zhenhua1 WU Dongchuan1 LI Jian1 ZHENG Yi1 WU Xiaoxia2 ZHAO Xuan1 TIAN Bin1
1.Department of Medical Neurology， Shengli Hospital of Shengli Petroleum Administration Bureau of Sinopec Group， Shandong Province， Dongying 257055， China； 2.Department of Cardiovascular， Shengli Hospital of Shengli Petroleum Administration Bureau of Sinopec Group， Shandong Province， Dongying 257055， China
[Abstract] Objective To investigate effect of transcranial direct current stimulation for non-motor symptoms of Parkinson's disease. Methods From June 2014 to June 2015， in Shandong Dongying Shengli Hospital of Shengli Petroleum Administration Bureau， 60 patients with non-motor symptoms of Parkinson's disease were selected as research subjects， according to random number table， patients were divided into treatment group and control group， with 30 cases in each group. Two groups were given drugs and rehabilitation exercises， the treatment group were given transcranial direct current stimulation on the basis of conventional therapy. After the treatment， Montreal cognitive assessment (MoCA)， Pittsburgh sleep quality index (PSQI)， quality of life (QOL) were as questionnaire， and the scores of two groups were compared. Results MoCA score of patients in control group before treatment was (15.2±2.7) scores， after treatment 10 d that was (21.2±2.0) scores， after treatment 20 d that was (30.0±1.3) scores， these of in treatment group were (16.7±3.6)， (24.1±2.9)， (36.0±2.1) scores， the scores of two groups before treatment were compared， the difference was not statistically significant (P > 0.05)， those after the treatment were compared， the differences were statistically significant (P < 0.05). PSQI score of patients in control group before treatment was (12.5±2.0) scores， after treatment 10 d that was (16.3±1.0) scores， after treatment 20 d that was (17.4±1.0) scores， these of in treatment group were (13.0±1.5)， (19.0±2.0)， (26.2±1.5) scores， the scores of two groups before treatment were compared， the difference was not statistically significant (P > 0.05)， those after the treatment were compared， the differences were statistically significant (P < 0.05). QOL score of patients in control group before treatment was (10.5±2.2) scores， after treatment 10 d that was (17.5±2.4) scores， after treatment 20 d that was (26.4±1.0) scores， these of in treatment group were (11.9±1.8)， (21.1±2.0)， (34.8±1.5) scores， the scores of two groups before treatment were compared， the difference was not statistically significant (P > 0.05)， those after the treatment were compared， the differences were statistically significant (P < 0.05). Conclusion Transcranial direct current stimulation can improve the non-motor symptoms and quality of life of patients with Parkinson's disease., 百拇医药(王广君 赵振华 吴东川 等)