血管钙化及其平滑肌细胞表型转化的调节机制(5)
[21] Zhu J，Shimizu E，Zhang X，et al. EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 andOsterix [J]. J Cell Biochem，2011，112(7)：1749-1760.
[22] Ding D，Li L，Song Y，et al. MAPK-ERK1/2 signaling pathway regulates osteogenic gene expression in rat osteoblasts in vitro [J]. J South Med Univ，2013，33(10)：1432-1436.
[23] Ge C，Yang Q，Zhao G，et al. Interactions between extracellular signal-regulated kinase 1/2 and P38 MAP kinase pathways in the control of Runx2 phosphorylation and transcriptional activity [J]. J Bone Miner Res，2012， 27(3)：538-551.
[24] Suzuki E，Ochiai-Shino H，Aoki H，et al. Akt Activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts [J]. PLoS One，2014， 9(12)：e112566.
[25] Qiu N，Zhou H，Xiao Z，et al. Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 Cells [J]. J Cell Biochem，2012，113(3)：967-976.
(收稿日期：2015-11-23 本文编辑：张瑜杰), 百拇医药(常晓丹 李丽华 张宝红)
[22] Ding D，Li L，Song Y，et al. MAPK-ERK1/2 signaling pathway regulates osteogenic gene expression in rat osteoblasts in vitro [J]. J South Med Univ，2013，33(10)：1432-1436.
[23] Ge C，Yang Q，Zhao G，et al. Interactions between extracellular signal-regulated kinase 1/2 and P38 MAP kinase pathways in the control of Runx2 phosphorylation and transcriptional activity [J]. J Bone Miner Res，2012， 27(3)：538-551.
[24] Suzuki E，Ochiai-Shino H，Aoki H，et al. Akt Activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts [J]. PLoS One，2014， 9(12)：e112566.
[25] Qiu N，Zhou H，Xiao Z，et al. Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 Cells [J]. J Cell Biochem，2012，113(3)：967-976.
(收稿日期：2015-11-23 本文编辑：张瑜杰), 百拇医药(常晓丹 李丽华 张宝红)