曲安奈德联合得宝松注射治疗瘢痕疙瘩的效果(1)
[摘要] 目的 探讨曲安奈德联合得宝松注射治疗瘢痕疙瘩的效果。 方法 选取2013年5月～2014年12月中国医学科学院北京协和医学院整形外科医院收治的瘢痕疙瘩患者150例，所有患者随机分为曲安奈德组、得宝松组和曲安奈德联合得宝松组，每组各50例。观察三组患者的临床疗效、不良反应及复发率。 结果 曲安奈德联合得宝松组患者总有效率为94.00%，明显高于曲安奈德组的70.00%，得宝松组的72.00%，差异有统计学意义(P < 0.05)。曲安奈德联合得宝松组患者的不良反应发生率为6.00%，明显低于曲安奈德组的14.00%及得宝松组的16.00%，差异有统计学意义(P < 0.05)。曲安奈德联合得宝松组患者6、12个月复发率明显低于曲安奈德组和得宝松组，差异有统计学意义(P < 0.05)。 结论 曲安奈德联合得宝松注射治疗瘢痕疙瘩的临床效果显著，值得临床推广应用。
[关键词] 曲安奈德；得宝松；瘢痕疙瘩；抑制；复发
[中图分类号] R619+.6 [文献标识码] A [文章编号] 1673-7210(2016)02(c)-0157-04
Effect of injection of Triamcinolone acetonide combined with Diprospan on the treatment of keloid
ZONG Xianlei SONG Guodong DU Le JIN Xiaolei▲
Sixteen Department of Plastic Surgery， Plastic Surgery Hospital of Beijing Union Medical College， Chinese Academy Medical Sciences， Beijing 100144， China
[Abstract] Objective To explore the effect of injection of triamcinolone acetonide and Diprospan on the treatment of keloid. Methods From May 2013 to December 2014， 150 keloid patients in Plastic Surgery Hospital of Beijing Union Medical Collge were selected and randomly divided into the triamcinolone acetonide group， the Diprospan group and the group of triamcinolone acetonide combined with Diprospan， with 50 cases in each group. The clinical effect， adverse reaction and the recurrence rate of the three groups were observed. Results The effective rate of the group of Triamcinolone acetonide combined with Diprospan was 94.00%， which was significantly higher than that of triamcinolone acetonide group with 70.00%， and Diprospan group with 72.00%. There were significant differences (P < 0.05). In the group of Triamcinolone acetonide combined with Diprospan， the incidence of adverse reactions was 6.00%， significantly lower than that of triamcinolone acetonide group with 14.00% and Diprospan group with 16.00%. There were significant differences (P < 0.05). For 6 and 12 months， the recurrence rate of the group of Triamcinolone acetonide combined with Diprospan was significantly lower than that of triamcinolone acetonide group and Diprospan group. There were significant differences (P < 0.05). Conclusion There is good clinical curative effect of injection Triamcinolone acetonide combined with Diprospan on the treatment of keloid， which is worthy of clinical application.
[Key words] Triamcinolone acetonide； Diprospan； Keloid； Inhibition； Recurrence
瘢痕疙瘩是一种伤口过度愈合所致的异常瘢痕，超出原伤口的界限， 以过剩胶原沉积为特征。瘢痕疙瘩具有发病率高、容易复发、治疗困难等特点。瘢痕疙瘩的常规治疗方法有药物注射治疗、a手术切除治疗、激光治疗、放射疗法、冷冻疗法、外用药物治疗等。其中，药物注射治疗疗效明确、安全性好、恢复较快、费用较低，患者的依从性较好，在瘢痕疙瘩治疗领域具有广泛的应用和重要的意义。药物注射治疗瘢痕疙瘩的机制主要有两个方面：①抑制成纤维细胞的增殖， 使成纤维细胞的胶原合成减少；②促进胶原降解，从而减少瘢痕疙瘩中胶原的沉积[1-3]。本研究拟探讨曲安奈德联合得宝松注射治疗瘢痕疙瘩的效果，希望借助药物之间的协同作用增强治疗效果，降低药物的不良反应，现报道如下：, http://www.100md.com(宗宪磊 宋国栋 都乐 靳小雷)
[关键词] 曲安奈德；得宝松；瘢痕疙瘩；抑制；复发
[中图分类号] R619+.6 [文献标识码] A [文章编号] 1673-7210(2016)02(c)-0157-04
Effect of injection of Triamcinolone acetonide combined with Diprospan on the treatment of keloid
ZONG Xianlei SONG Guodong DU Le JIN Xiaolei▲
Sixteen Department of Plastic Surgery， Plastic Surgery Hospital of Beijing Union Medical College， Chinese Academy Medical Sciences， Beijing 100144， China
[Abstract] Objective To explore the effect of injection of triamcinolone acetonide and Diprospan on the treatment of keloid. Methods From May 2013 to December 2014， 150 keloid patients in Plastic Surgery Hospital of Beijing Union Medical Collge were selected and randomly divided into the triamcinolone acetonide group， the Diprospan group and the group of triamcinolone acetonide combined with Diprospan， with 50 cases in each group. The clinical effect， adverse reaction and the recurrence rate of the three groups were observed. Results The effective rate of the group of Triamcinolone acetonide combined with Diprospan was 94.00%， which was significantly higher than that of triamcinolone acetonide group with 70.00%， and Diprospan group with 72.00%. There were significant differences (P < 0.05). In the group of Triamcinolone acetonide combined with Diprospan， the incidence of adverse reactions was 6.00%， significantly lower than that of triamcinolone acetonide group with 14.00% and Diprospan group with 16.00%. There were significant differences (P < 0.05). For 6 and 12 months， the recurrence rate of the group of Triamcinolone acetonide combined with Diprospan was significantly lower than that of triamcinolone acetonide group and Diprospan group. There were significant differences (P < 0.05). Conclusion There is good clinical curative effect of injection Triamcinolone acetonide combined with Diprospan on the treatment of keloid， which is worthy of clinical application.
[Key words] Triamcinolone acetonide； Diprospan； Keloid； Inhibition； Recurrence
瘢痕疙瘩是一种伤口过度愈合所致的异常瘢痕，超出原伤口的界限， 以过剩胶原沉积为特征。瘢痕疙瘩具有发病率高、容易复发、治疗困难等特点。瘢痕疙瘩的常规治疗方法有药物注射治疗、a手术切除治疗、激光治疗、放射疗法、冷冻疗法、外用药物治疗等。其中，药物注射治疗疗效明确、安全性好、恢复较快、费用较低，患者的依从性较好，在瘢痕疙瘩治疗领域具有广泛的应用和重要的意义。药物注射治疗瘢痕疙瘩的机制主要有两个方面：①抑制成纤维细胞的增殖， 使成纤维细胞的胶原合成减少；②促进胶原降解，从而减少瘢痕疙瘩中胶原的沉积[1-3]。本研究拟探讨曲安奈德联合得宝松注射治疗瘢痕疙瘩的效果，希望借助药物之间的协同作用增强治疗效果，降低药物的不良反应，现报道如下：, http://www.100md.com(宗宪磊 宋国栋 都乐 靳小雷)