刺五加根的抗炎活性成分研究(1)
[摘要] 目的 研究刺五加根的抗炎活性成分。 方法 脂多糖(LPS)和干扰素(IFN-γ)诱导的单核巨噬细胞RAW264.7作为细胞炎症模型，考察了刺五加根提取物对一氧化氮(NO)释放抑制活性，利用HPD100大孔吸附树脂、硅胶柱层析、反相色谱柱(ODS)、凝胶色谱、半制备高效液相等色谱技术对其进行化学成分分离，并运用薄层色谱法，红外光谱、核磁等波谱技术确定化合物的结构。 结果 刺五加根提取物具有抑制NO释放活性，从中分离得到7个化合物，分别鉴定为紫丁香苷、刺五加苷B1、刺五加苷E、芝麻素、胡萝卜苷、β-谷甾醇和香草酸。 结论 刺五加根提取物具有抗炎活性，其中的苯丙素类成分为其抗炎活性成分。
[关键词] 刺五加根；化学成分；抗炎活性；一氧化氮
[中图分类号] R961.1 [文献标识码] A [文章编号] 1673-7210(2016)05(a)-0020-04
[Abstract] Objective To study the anti-inflammatory constituents of Acanthopanax senticosus. Methods NO production in the activated RAW 264.7 macrophages induced by LPS and IFN-γ were used to evaluate anti-inflammatory activity. The compounds were isolated by HPD 100 resin ......
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[关键词] 刺五加根；化学成分；抗炎活性；一氧化氮
[中图分类号] R961.1 [文献标识码] A [文章编号] 1673-7210(2016)05(a)-0020-04
[Abstract] Objective To study the anti-inflammatory constituents of Acanthopanax senticosus. Methods NO production in the activated RAW 264.7 macrophages induced by LPS and IFN-γ were used to evaluate anti-inflammatory activity. The compounds were isolated by HPD 100 resin ......
您现在查看是摘要页，全文长 3678 字符。