尼洛替尼治疗以胸腔积液为首发的慢性髓系白血病2例及文献复习(1)
[摘要] 2例以胸腔积液为首发的慢性髓系白血病患者初诊时即为急变期，予尼洛替尼治疗后，例1治疗1个月余，胸腔积液基本完全吸收，淋巴结和脾脏肿大基本消失，治疗12个月，获得分子学反应。例2治疗20 d，也表现为淋巴结和脾脏肿大逐渐缩小，胸腔积液逐渐消失，但患者骨髓抑制明显，停止尼洛替尼治疗后胸腔积液再次出现。本文通过对2例患者临床资料进行回顾分析及复习相关文献，提示尼洛替尼可能成为治疗以胸腔积液首发的慢性髓系白血病患者的首选药物，有利于胸腔积液的吸收，有望达到分子学缓解。
[关键词] 尼洛替尼；慢性髓系白血病；急变期；胸腔积液
[中图分类号] R733.72 [文献标识码] A [文章编号] 1673-7210(2016)05(c)-0166-04
[Abstract] Two cases of patients with chronic myeloid leukemia-blast crisis (CML-BC) with the initial symptoms of pleural effusion were given Nilotinib. Pleural effusion of case 1 was almost completely absorbed and lymph nodes and splenomegaly were disappeared 1 month after treatment. It had a molecular response after 12 months. The case 2 also showed that pleural effusion disappeared gradually and the lymph nodes and splenomegaly became smaller 20 days after treatment. It had significantly inhibition of bone marrow. The pleural effusion appeared again after stopping the treatment with Nilotinib. The clinical data of 2 CML-BC patients with the onset of pleural effusion was retrospectively analyzed and related literature was also reviewed ......
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[关键词] 尼洛替尼；慢性髓系白血病；急变期；胸腔积液
[中图分类号] R733.72 [文献标识码] A [文章编号] 1673-7210(2016)05(c)-0166-04
[Abstract] Two cases of patients with chronic myeloid leukemia-blast crisis (CML-BC) with the initial symptoms of pleural effusion were given Nilotinib. Pleural effusion of case 1 was almost completely absorbed and lymph nodes and splenomegaly were disappeared 1 month after treatment. It had a molecular response after 12 months. The case 2 also showed that pleural effusion disappeared gradually and the lymph nodes and splenomegaly became smaller 20 days after treatment. It had significantly inhibition of bone marrow. The pleural effusion appeared again after stopping the treatment with Nilotinib. The clinical data of 2 CML-BC patients with the onset of pleural effusion was retrospectively analyzed and related literature was also reviewed ......
您现在查看是摘要页，全文长 4221 字符。