RealtimePCR检测L1—CAM在大肠癌中的表达及其临床意义(1)
[摘要] 目的 探讨L1细胞黏附分子(L1-CAM)在大肠癌中的表达情况及其与临床病理的相关性。 方法 应用实时荧光定量PCR检测浙江省人民医院58例大肠癌组织及其癌旁正常组织中L1-CAM的表达，分析L1-CAM在大肠癌中的表达及其与临床病理学特征和预后的关系。 结果 癌组织和癌旁正常组织L1-CAM mRNA表达差异有统计学意义(P < 0.05)。癌组织L1-CAM mRNA表达与肿瘤分化程度、静脉侵犯、淋巴管侵犯、淋巴结转移、Dukes分期密切相关(均P < 0.05)，而与性别、年龄、肿瘤大小、肿瘤类型无明显相关(均P > 0.05)。 结论 L1-CAM在大肠癌组织中高表达，并且与大肠癌的浸润、转移有关。
[关键词] 大肠癌；L1细胞黏附分子；实时荧光定量PCR
[中图分类号] R735.35 [文献标识码] A [文章编号] 1673-7210(2016)09(b)-0092-04
[Abstract] Objective To investigate the L1-CAM mRNA expression in cancerous tissue of patients with colorectal carcinoma and to evaluate the relationship between L1-CAM mRNA expression and clinicopathological significance. Methods Cancerous tissue and para-carcinoma tissue samples were collected from 58 patients with colorectal carcinoma from Zhejiang Provincial People's Hospital. Real time PCR was used to detect the L1-CAM mRNA expression in cancerous tissue and para-carcinoma tissue ......
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[关键词] 大肠癌；L1细胞黏附分子；实时荧光定量PCR
[中图分类号] R735.35 [文献标识码] A [文章编号] 1673-7210(2016)09(b)-0092-04
[Abstract] Objective To investigate the L1-CAM mRNA expression in cancerous tissue of patients with colorectal carcinoma and to evaluate the relationship between L1-CAM mRNA expression and clinicopathological significance. Methods Cancerous tissue and para-carcinoma tissue samples were collected from 58 patients with colorectal carcinoma from Zhejiang Provincial People's Hospital. Real time PCR was used to detect the L1-CAM mRNA expression in cancerous tissue and para-carcinoma tissue ......
您现在查看是摘要页，全文长 3449 字符。