影响帕金森病患者选择不同治疗方式相关因素的Logistic回归分析(1)
[摘要] 目的 探讨帕金森病(PD)患者选择不同治疗方式的可能的独立客观影响因素。 方法 随机选取2013年1月～2016年1月就诊于武警后勤学院附属医院的122例PD患者。根据患者首次就诊接受治疗方式的不同分为两组，即：单纯药物治疗组61例，脑深部电刺激(DBS)治疗组61例。对性别、年龄、病程、临床表现、既往史、治疗药物用法及用量等客观因素进行Logistic回归分析，逐步筛选可能影响PD患者选择不同治疗方式的独立客观因素。 结果 单因素分析的结果显示，影响PD患者选择不同治疗方式的客观因素可能包括受累侧别(χ2=6.517，P=0.011)、临床类型(χ2=53.738，P=0.000)、受累肢体个数(χ2=30.458，P=0.000)、左旋多巴类药物日剂量(χ2=43.971，P=0.011)、应用治疗药物总类数(χ2=10.600，P=0.031)。多因素非条件Logistic回归分析结果显示，影响PD患者选择不同治疗方式的独立客观因素可能为受累侧别(OR=3.549，95%CI：1.061～11.869，P=0.040)、左旋多巴类药物日剂量(OR=1.002，95%CI：1.001～1.004，P=0.003)。 结论 PD患者选择不同治疗方式可能受受累侧别、临床类型、受累肢体个数、左旋多巴类药物日剂量、应用治疗药物总类数等客观因素影响。其中，受累侧别以及左旋多巴类药物日剂量可能是影响患者选择不同治疗方式的独立客观影响因素。
[关键词] 帕金森病；治疗；Logistic回归分析
[中图分类号] R742 [文献标识码] A [文章编号] 1674-4721(2016)09(b)-0128-04
[Abstract] Objective To explore the main potential objective factors that affecting choices of different treatment methods which were made by Parkinson's disease. Methods 122 participants with detailed clinical data including gender， age， course of disease， clinical manifestation， history of past illness， usage and dosages who came from Affiliated Hospital of Logistics University of People′s Armed Police Force from January 2013 to January 2016 were selected. According to the different methods of treatment， the patients were randomized to optimal drug therapy (ODT) group (n = 61) or deep brain stimulation (DBS) group (n = 61). Logistic regression was used to analyze the above factors， and selected the potential factors influenced the therapy method selection in patients with Parkinson′s disease. Results The results of univariate Logistic regression showed that affected side (χ2=6.517， P=0.011)， clinical types (χ2=53.738， P=0.000)， number of affected limbs (χ2 =30.458， P=0.000)， average daily dose of L-DOPA medicine (χ2 =43.971， P=0.011)， number of drugs application for the treatment (χ2=10.600， P =0.031) were probably associated with choice of different treatment modalities. Non-conditional Logistic regression for analyzing the above factors found that affected side (OR=3.549， 95%CI： 1.061-11.869， P=0.040)， average daily dose of L-DOPA medicine (OR=1.002， 95%CI：1.001-1.004， P=0.003) might be the potential promoting factors (P < 0.05). Conclusion The choices of different treatment methods are probably affected by affected side， clinical types， number of affected limbs， average daily dose of L-DOPA medicine， number of drugs application for the treatment； among which， affected side and average daily dose of L-DOPA medicine may be the independent objective factors in terms of the choice of treatment. (国树超 杨俊秀 张海博)
[关键词] 帕金森病；治疗；Logistic回归分析
[中图分类号] R742 [文献标识码] A [文章编号] 1674-4721(2016)09(b)-0128-04
[Abstract] Objective To explore the main potential objective factors that affecting choices of different treatment methods which were made by Parkinson's disease. Methods 122 participants with detailed clinical data including gender， age， course of disease， clinical manifestation， history of past illness， usage and dosages who came from Affiliated Hospital of Logistics University of People′s Armed Police Force from January 2013 to January 2016 were selected. According to the different methods of treatment， the patients were randomized to optimal drug therapy (ODT) group (n = 61) or deep brain stimulation (DBS) group (n = 61). Logistic regression was used to analyze the above factors， and selected the potential factors influenced the therapy method selection in patients with Parkinson′s disease. Results The results of univariate Logistic regression showed that affected side (χ2=6.517， P=0.011)， clinical types (χ2=53.738， P=0.000)， number of affected limbs (χ2 =30.458， P=0.000)， average daily dose of L-DOPA medicine (χ2 =43.971， P=0.011)， number of drugs application for the treatment (χ2=10.600， P =0.031) were probably associated with choice of different treatment modalities. Non-conditional Logistic regression for analyzing the above factors found that affected side (OR=3.549， 95%CI： 1.061-11.869， P=0.040)， average daily dose of L-DOPA medicine (OR=1.002， 95%CI：1.001-1.004， P=0.003) might be the potential promoting factors (P < 0.05). Conclusion The choices of different treatment methods are probably affected by affected side， clinical types， number of affected limbs， average daily dose of L-DOPA medicine， number of drugs application for the treatment； among which， affected side and average daily dose of L-DOPA medicine may be the independent objective factors in terms of the choice of treatment. (国树超 杨俊秀 张海博)